Human Gene Set: LINSLEY_MIR16_TARGETS


Standard name LINSLEY_MIR16_TARGETS
Systematic name M2284
Brief description Transcripts down-regulated by overexpression of MIR16 family of microRNA molecules in DLD-1 and HCT116 (colon cancer) cells hypomorphic for DICER1 [GeneID=23405].
Full description or abstract microRNAs (miRNAs) are abundant, approximately 21-nucleotide, noncoding regulatory RNAs. Each miRNA may regulate hundreds of mRNA targets, but the identities of these targets and the processes they regulate are poorly understood. Here we have explored the use of microarray profiling and functional screening to identify targets and biological processes triggered by the transfection of human cells with miRNAs. We demonstrate that a family of miRNAs sharing sequence identity with miRNA-16 (miR-16) negatively regulates cellular growth and cell cycle progression. miR-16-down-regulated transcripts were enriched with genes whose silencing by small interfering RNAs causes an accumulation of cells in G(0)/G(1). Simultaneous silencing of these genes was more effective at blocking cell cycle progression than disruption of the individual genes. Thus, miR-16 coordinately regulates targets that may act in concert to control cell cycle progression.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 17242205   Authors: Linsley PS,Schelter J,Burchard J,Kibukawa M,Martin MM,Bartz SR,Johnson JM,Cummins JM,Raymond CK,Dai H,Chau N,Cleary M,Jackson AL,Carleton M,Lim L
Exact source Table 4S
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Source species Homo sapiens
Contributed by Arthur Liberzon (MSigDB Team)
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identifier namespace		 HUMAN_GENE_SYMBOL
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Version history 3.1: First introduced

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