Human Gene Set: LEE_BRCAGENIE_PRS_POS


Standard name LEE_BRCAGENIE_PRS_POS
Systematic name M50218
Brief description Genes from the 107-gene BRCAGenie PRS model (without forward stepwise selection) with positive multivariate Cox coefficients; identified via hypothesis-free machine learning of the TCGA-BRCA cohort.
Full description or abstract This study conducted a machine learning-based survival analysis on the Cancer Genome Atlas Breast Cancer (TCGA-BRCA) cohort, the authors identified a novel gene signature for a robust polygenic risk score (PRS) model. Feature selection involving univariate Cox and LASSO Cox regression constructed a 107-gene PRS model after LASSO Cox regression but before forward stepwise selection. These specific genes exhibit positive multivariate Cox coefficients.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 41162968   Authors: Lee JW,Lim AJW,Wang C,Neo JH,Lim LJ,Chong SS,Lee CG
Exact source 12967_2025_7100_MOESM1_ESM.xlsx, Table S4. Genes with a Positive Multivariate Cox Coefficient.
Related gene sets (show 1 additional gene sets from the source publication)

(show 8 gene sets from any of these authors)
External links https://pmc.ncbi.nlm.nih.gov/articles/PMC12574034/
Filtered by similarity ?
Source species Homo sapiens
Contributed by Anthony Castanza (MSigDB Team)
Source platform or
identifier namespace		 HUMAN_GENE_SYMBOL
Dataset references  
Download gene set format: grp | gmt | xml | json | TSV metadata
Compute overlaps ? (show collections to investigate for overlap with this gene set)
Compendia expression profiles ? NG-CHM interactive heatmaps
(Please note that clustering takes a few seconds)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)

Legacy heatmaps (PNG)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query Further investigate these 58 genes
Gene families ? Categorize these 58 genes by gene family
Show members (show 59 source identifiers mapped to 58 genes)
Version history 2026.1.Hs: First Introduced.


Creative Commons Attribution 4.0 International License (CC-BY-4.0)

The contents of this gene set are protected by copyright (c) 2004-2026 Broad Institute, Inc., Massachusetts Institute of Technology, and Regents of the University of California, subject to the terms and conditions of the Creative Commons Attribution 4.0 International License.

See the full MSigDB license terms here.