Human Gene Set: LEE_BRCAGENIE_PRS_NEG


Standard name LEE_BRCAGENIE_PRS_NEG
Systematic name M50219
Brief description Genes from the 107-gene BRCAGenie PRS model (without forward stepwise selection) with negative multivariate Cox coefficients; identified via hypothesis-free machine learning of the TCGA-BRCA cohort.
Full description or abstract This study conducted a machine learning-based survival analysis on the Cancer Genome Atlas Breast Cancer (TCGA-BRCA) cohort, the authors identified a novel gene signature for a robust polygenic risk score (PRS) model. Feature selection involving univariate Cox and LASSO Cox regression constructed a 107-gene PRS model after LASSO Cox regression but before forward stepwise selection. These specific genes exhibit negative multivariate Cox coefficients.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 41162968   Authors: Lee JW,Lim AJW,Wang C,Neo JH,Lim LJ,Chong SS,Lee CG
Exact source 12967_2025_7100_MOESM1_ESM.xlsx, Table S4. Genes with a Negative Multivariate Cox Coefficient.
Related gene sets (show 1 additional gene sets from the source publication)

(show 8 gene sets from any of these authors)
External links https://pmc.ncbi.nlm.nih.gov/articles/PMC12574034/
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Source species Homo sapiens
Contributed by Anthony Castanza (MSigDB Team)
Source platform or
identifier namespace		 HUMAN_GENE_SYMBOL
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Version history 2026.1.Hs: First Introduced.


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