Human Gene Set: LAMB_CCND1_TARGETS


Standard name LAMB_CCND1_TARGETS
Systematic name M2935
Brief description The cyclin D1 signature: genes whose expression correlated with the levels of CCND1 [GeneID=595].
Full description or abstract Here we describe how patterns of gene expression in human tumors have been deconvoluted to reveal a mechanism of action for the cyclin D1 oncogene. Computational analysis of the expression patterns of thousands of genes across hundreds of tumor specimens suggested that a transcription factor, C/EBPbeta/Nf-Il6, participates in the consequences of cyclin D1 overexpression. Functional analyses confirmed the involvement of C/EBPbeta in the regulation of genes affected by cyclin D1 and established this protein as an indispensable effector of a potentially important facet of cyclin D1 biology. This work demonstrates that tumor gene expression databases can be used to study the function of a human oncogene in situ.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 12914697   Authors: Lamb J,Ramaswamy S,Ford HL,Contreras B,Martinez RV,Kittrell FS,Zahnow CA,Patterson N,Golub TR,Ewen ME
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Source species Homo sapiens
Contributed by Jean Junior (MSigDB Team)
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identifier namespace		 AFFY_HuGene
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Version history 3.0: Renamed from LAMB_CYCLIN_D1_UP

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