Human Gene Set: KEGG_N_GLYCAN_BIOSYNTHESIS


Standard name KEGG_N_GLYCAN_BIOSYNTHESIS
Systematic name M11079
Brief description N-Glycan biosynthesis
Full description or abstract N-glycans or asparagine-linked glycans are major constituents of glycoproteins in eukaryotes. N-glycans are covalently attached to asparagine with the consensus sequence of Asn-X-Ser/Thr by an N-glycosidic bond, GlcNAc b1- Asn. Biosynthesis of N-glycans begins on the cytoplasmic face of the ER membrane with the transferase reaction of UDP-GlcNAc and the lipid-like precursor P-Dol (dolichol phosphate) to generate GlcNAc a1- PP-Dol. After sequential addition of monosaccharides by ALG glycosyltransferases, the N-glycan precursor is attached by the OST (oligosaccharyltransferase) complex to the polypeptide chain that is being synthesized and translocated through the ER membrane. The protein-bound N-glycan precursor is subsequently trimmed, extended, and modified in the ER and Golgi by a complex series of reactions catalyzed by membrane-bound glycosidases and glycosyltransferases. N-glycans thus synthesized are classified into three types: high-mannose type, complex type, and hybrid type. Defects in N-glycan biosynthesis lead to a variety of human diseases known as congenital disorders of glycosylation.
Collection C2: Curated
      CP: Canonical Pathways
            CP:KEGG_LEGACY: KEGG Legacy Pathways
Source publication  
Exact source hsa00510
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External links http://www.genome.jp/pathway/hsa00510
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Source species Homo sapiens
Contributed by KEGG (Kyoto Encyclopedia of Genes and Genomes)
Source platform or
identifier namespace		 Human_NCBI_Gene_ID
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Version history  

The content of the gene sets in the KEGG_LEGACY collection has not been updated since KEGG restricted their usage terms in 2011. More recent sets are available in the KEGG_MEDICUS collection, derived from KEGG's openly available MEDICUS subset.



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MSigDB gene sets derived from Legacy KEGG pathways are protected by copyright, (c) 1995-2017 Kanehisa Laboratories, all rights reserved. They are provided for use in the MSigDB collection under license to the Broad Institute, Inc., with qualified permission to include in this release. End users are directed to http://www.pathway.jp/ and http://www.kegg.jp/kegg/docs/plea.html for information on the copyright holder's academic and commercial licensing policies. Inclusion of these gene sets herein is conditioned upon acknowledgment and retention of the aforementioned copyright, and compliance with such policies. These KEGG derived gene sets are in a subcollection MSigDB C2 named "KEGG_LEGACY", and can be recognized by the "KEGG_" prefix (without "MEDICUS") in their name.

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