| Standard name |
KEGG_NON_HOMOLOGOUS_END_JOINING |
| Systematic name |
M7857 |
| Brief description |
Non-homologous end-joining |
| Full description or abstract |
Nonhomologous end joining (NHEJ) eliminates DNA double-strand breaks (DSBs) by direct ligation. NHEJ involves binding of the KU heterodimer to double-stranded DNA ends, recruitment of DNA-PKcs (MRX complex in yeast), processing of ends, and recruitment of the DNA ligase IV (LIG4)-XRCC4 complex, which brings about ligation. A recent study shows that bacteria accomplish NHEJ using just two proteins (Ku and DNA ligase), whereas eukaryotes require many factors. NHEJ repairs DSBs at all stages of the cell cycle, bringing about the ligation of two DNA DSBs without the need for sequence homology, and so is error-prone. |
| Collection |
C2: Curated
CP: Canonical Pathways
CP:KEGG_LEGACY: KEGG Legacy Pathways |
| Source publication |
|
| Exact source |
hsa03450 |
| Related gene sets |
|
| External links |
http://www.genome.jp/pathway/hsa03450
|
| Filtered by similarity ?
|
|
| Source species |
Homo sapiens |
| Contributed by |
KEGG (Kyoto Encyclopedia of Genes and Genomes) |
Source platform or
identifier namespace |
Human_NCBI_Gene_ID |
| Dataset references |
|
| Download gene set |
format: grp | gmt | xml | json | TSV metadata |
| Compute overlaps ? |
(show collections to investigate for overlap with this gene set)
|
| Compendia expression profiles ? |
NG-CHM interactive heatmaps
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GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Legacy heatmaps (PNG)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
|
| Advanced query |
Further investigate
these 13 genes
|
| Gene families ? |
Categorize these
13 genes by gene family
|
| Show members |
(show 14 source identifiers mapped to 13 genes)
Source
Id |
NCBI (Entrez)
Gene Id |
Gene
Symbol |
Gene
Description |
| 10111 |
10111 |
RAD50 |
RAD50 double strand break repair protein [So... |
| 1791 |
1791 |
DNTT |
DNA nucleotidylexotransferase [Source:HGNC S... |
| 2237 |
2237 |
FEN1 |
flap structure-specific endonuclease 1 [Sour... |
| 2547 |
2547 |
XRCC6 |
X-ray repair cross complementing 6 [Source:H... |
| 27343 |
27343 |
POLL |
DNA polymerase lambda [Source:HGNC Symbol;Ac... |
| 27434 |
27434 |
POLM |
DNA polymerase mu [Source:HGNC Symbol;Acc:HG... |
| 3981 |
3981 |
LIG4 |
DNA ligase 4 [Source:HGNC Symbol;Acc:HGNC:6601] |
| 4361 |
4361 |
MRE11 |
MRE11 homolog, double strand break repair nu... |
| 5591 |
5591 |
PRKDC |
protein kinase, DNA-activated, catalytic sub... |
| 64421 |
64421 |
DCLRE1C |
DNA cross-link repair 1C [Source:HGNC Symbol... |
| 731751 |
|
|
|
| 7518 |
7518 |
XRCC4 |
X-ray repair cross complementing 4 [Source:H... |
| 7520 |
7520 |
XRCC5 |
X-ray repair cross complementing 5 [Source:H... |
| 79840 |
79840 |
NHEJ1 |
non-homologous end joining factor 1 [Source:... |
|
| Version history |
|
The content of the gene sets in the KEGG_LEGACY collection has not been updated since KEGG
restricted their usage terms in 2011. More recent sets are available in the KEGG_MEDICUS
collection, derived from KEGG's openly available MEDICUS subset.
