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Human Gene Set: KEGG_MEDICUS_VARIANT_NOTCH_OVEREXPRESSION_TO_NOTCH_SIGNALING_PATHWAY
Standard name
KEGG_MEDICUS_VARIANT_NOTCH_OVEREXPRESSION_TO_NOTCH_SIGNALING_PATHWAY
Systematic name
M47424
Brief description
Pathway Definition from KEGG: (DLL,JAG) -> (NOTCH1*,NOTCH4*) -> (NICD+RBPJ) => (ERBB2,HES1,HES5,HEY,FLT4)
Full description or abstract
NOTCH-overexpression to Notch signaling pathway. Pathway ID: N00087. Pathway type: Variant. Pathway class: nt06270 Breast cancer.
Collection
C2: Curated
CP: Canonical Pathways
CP:KEGG_MEDICUS: KEGG Medicus Pathways
Source publication
Exact source
N00087
Related gene sets
External links
https://www.kegg.jp/entry/N00087
Filtered by similarity
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Source species
Homo sapiens
Contributed by
KEGG (Kyoto Encyclopedia of Genes and Genomes)
Source platform or
identifier namespace
Human_NCBI_Gene_ID
Dataset references
Download gene set
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grp
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gmt
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xml
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TSV metadata
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H: Hallmark
C1: Positional
C2: Curated
CGP: Chemical and Genetic Perturbations
CP: Canonical Pathways
CP:BIOCARTA: BioCarta Pathways
CP:KEGG_MEDICUS: KEGG Medicus Pathways
CP:PID: PID Pathways
CP:REACTOME: Reactome Pathways
CP:WIKIPATHWAYS: WikiPathways
CP:KEGG_LEGACY: KEGG Legacy Pathways
C3: Regulatory Target
MIR: microRNA Targets
MIR:MIRDB: miRDB
MIR:MIR_LEGACY: MIR_Legacy
TFT: Transcription Factor Targets
TFT:GTRD: GTRD
TFT:TFT_LEGACY: TFT_Legacy
C4: Computational
3CA: Curated Cancer Cell Atlas gene sets
CGN: Cancer Gene Neighborhoods
CM: Cancer Modules
C5: Ontology
GO: Gene Ontology
GO:BP: GO Biological Process
GO:CC: GO Cellular Component
GO:MF: GO Molecular Function
HPO: Human Phenotype Ontology
C6: Oncogenic Signature
C7: Immunologic Signature
IMMUNESIGDB: ImmuneSigDB
VAX: HIPC Vaccine Response
C8: Cell Type Signature
Compendia expression profiles
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NG-CHM interactive heatmaps
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GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Legacy heatmaps (PNG)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query
Further investigate
these 16 genes
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Show members
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16 source identifiers mapped to 16 genes)
Source
Id
NCBI (Entrez)
Gene Id
Gene
Symbol
Gene
Description
10683
10683
DLL3
delta like canonical Notch ligand 3 [Source:...
11317
11317
RBPJL
recombination signal binding protein for imm...
182
182
JAG1
jagged canonical Notch ligand 1 [Source:HGNC...
2064
2064
ERBB2
erb-b2 receptor tyrosine kinase 2 [Source:HG...
2324
2324
FLT4
fms related receptor tyrosine kinase 4 [Sour...
23462
23462
HEY1
hes related family bHLH transcription factor...
23493
23493
HEY2
hes related family bHLH transcription factor...
26508
26508
HEYL
hes related family bHLH transcription factor...
28514
28514
DLL1
delta like canonical Notch ligand 1 [Source:...
3280
3280
HES1
hes family bHLH transcription factor 1 [Sour...
3516
3516
RBPJ
recombination signal binding protein for imm...
3714
3714
JAG2
jagged canonical Notch ligand 2 [Source:HGNC...
388585
388585
HES5
hes family bHLH transcription factor 5 [Sour...
4851
4851
NOTCH1
notch receptor 1 [Source:HGNC Symbol;Acc:HGN...
4855
4855
NOTCH4
notch receptor 4 [Source:HGNC Symbol;Acc:HGN...
54567
54567
DLL4
delta like canonical Notch ligand 4 [Source:...
Version history
2024.1.Hs: Updated to network file downloaded on 2024-05-205
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