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Human Gene Set: KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_LRRK2_TO_INTRINSIC_APOPTOTIC_PATHWAY
Standard name
KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_LRRK2_TO_INTRINSIC_APOPTOTIC_PATHWAY
Systematic name
M48979
Brief description
Pathway Definition from KEGG: LRRK2* -> CYCS == APAF1 -> CASP9 -> CASP3
Full description or abstract
Mutation-activated LRRK2 to intrinsic apoptotic pathway. Pathway ID: N01047. Pathway type: Variant. Pathway class: nt06463 Parkinson disease.
Collection
C2: Curated
CP: Canonical Pathways
CP:KEGG_MEDICUS: KEGG Medicus Pathways
Source publication
Exact source
N01047
Related gene sets
External links
https://www.kegg.jp/entry/N01047
Filtered by similarity
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Source species
Homo sapiens
Contributed by
KEGG (Kyoto Encyclopedia of Genes and Genomes)
Source platform or
identifier namespace
Human_NCBI_Gene_ID
Dataset references
Download gene set
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grp
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gmt
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TSV metadata
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H: Hallmark
C1: Positional
C2: Curated
CGP: Chemical and Genetic Perturbations
CP: Canonical Pathways
CP:BIOCARTA: BioCarta Pathways
CP:KEGG_MEDICUS: KEGG Medicus Pathways
CP:PID: PID Pathways
CP:REACTOME: Reactome Pathways
CP:WIKIPATHWAYS: WikiPathways
CP:KEGG_LEGACY: KEGG Legacy Pathways
C3: Regulatory Target
MIR: microRNA Targets
MIR:MIRDB: miRDB
MIR:MIR_LEGACY: MIR_Legacy
TFT: Transcription Factor Targets
TFT:GTRD: GTRD
TFT:TFT_LEGACY: TFT_Legacy
C4: Computational
3CA: Curated Cancer Cell Atlas gene sets
CGN: Cancer Gene Neighborhoods
CM: Cancer Modules
C5: Ontology
GO: Gene Ontology
GO:BP: GO Biological Process
GO:CC: GO Cellular Component
GO:MF: GO Molecular Function
HPO: Human Phenotype Ontology
C6: Oncogenic Signature
C7: Immunologic Signature
IMMUNESIGDB: ImmuneSigDB
VAX: HIPC Vaccine Response
C8: Cell Type Signature
Compendia expression profiles
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GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Legacy heatmaps (PNG)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query
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these 5 genes
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Show members
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5 source identifiers mapped to 5 genes)
Source
Id
NCBI (Entrez)
Gene Id
Gene
Symbol
Gene
Description
120892
120892
LRRK2
leucine rich repeat kinase 2 [Source:HGNC Sym...
317
317
APAF1
apoptotic peptidase activating factor 1 [Sour...
54205
54205
CYCS
cytochrome c, somatic [Source:HGNC Symbol;Acc...
836
836
CASP3
caspase 3 [Source:HGNC Symbol;Acc:HGNC:1504]
842
842
CASP9
caspase 9 [Source:HGNC Symbol;Acc:HGNC:1511]
Version history
2024.1.Hs: Updated to network file downloaded on 2024-05-60
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