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Human Gene Set: KEGG_MEDICUS_VARIANT_MET_OVEREXPRESSION_TO_RAS_ERK_SIGNALING_PATHWAY
Standard name
KEGG_MEDICUS_VARIANT_MET_OVEREXPRESSION_TO_RAS_ERK_SIGNALING_PATHWAY
Systematic name
M47488
Brief description
Pathway Definition from KEGG: MET* -> GRB2 -> SOS -> RAS -> RAF -> MEK -> ERK
Full description or abstract
MET-overexpression to RAS-ERK signaling pathway. Pathway ID: N00248. Pathway type: Variant. Pathway class: nt06263 Hepatocellular carcinoma.
Collection
C2: Curated
CP: Canonical Pathways
CP:KEGG_MEDICUS: KEGG Medicus Pathways
Source publication
Exact source
N00248
Related gene sets
External links
https://www.kegg.jp/entry/N00248
Filtered by similarity
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2 similar term(s) from the external resource)
External ID
External Name
N00259
Amplified MET to RAS-ERK signaling pathway
N01062
Mutation-activated MET to RAS-ERK signaling pathway
Source species
Homo sapiens
Contributed by
KEGG (Kyoto Encyclopedia of Genes and Genomes)
Source platform or
identifier namespace
Human_NCBI_Gene_ID
Dataset references
Download gene set
format:
grp
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TSV metadata
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H: Hallmark
C1: Positional
C2: Curated
CGP: Chemical and Genetic Perturbations
CP: Canonical Pathways
CP:BIOCARTA: BioCarta Pathways
CP:KEGG_MEDICUS: KEGG Medicus Pathways
CP:PID: PID Pathways
CP:REACTOME: Reactome Pathways
CP:WIKIPATHWAYS: WikiPathways
CP:KEGG_LEGACY: KEGG Legacy Pathways
C3: Regulatory Target
MIR: microRNA Targets
MIR:MIRDB: miRDB
MIR:MIR_LEGACY: MIR_Legacy
TFT: Transcription Factor Targets
TFT:GTRD: GTRD
TFT:TFT_LEGACY: TFT_Legacy
C4: Computational
3CA: Curated Cancer Cell Atlas gene sets
CGN: Cancer Gene Neighborhoods
CM: Cancer Modules
C5: Ontology
GO: Gene Ontology
GO:BP: GO Biological Process
GO:CC: GO Cellular Component
GO:MF: GO Molecular Function
HPO: Human Phenotype Ontology
C6: Oncogenic Signature
C7: Immunologic Signature
IMMUNESIGDB: ImmuneSigDB
VAX: HIPC Vaccine Response
C8: Cell Type Signature
Compendia expression profiles
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GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Legacy heatmaps (PNG)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query
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Show members
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14 source identifiers mapped to 14 genes)
Source
Id
NCBI (Entrez)
Gene Id
Gene
Symbol
Gene
Description
2885
2885
GRB2
growth factor receptor bound protein 2 [Source:H...
3265
3265
HRAS
HRas proto-oncogene, GTPase [Source:HGNC Symbol;...
369
369
ARAF
A-Raf proto-oncogene, serine/threonine kinase [S...
3845
3845
KRAS
KRAS proto-oncogene, GTPase [Source:HGNC Symbol;...
4233
4233
MET
MET proto-oncogene, receptor tyrosine kinase [So...
4893
4893
NRAS
NRAS proto-oncogene, GTPase [Source:HGNC Symbol;...
5594
5594
MAPK1
mitogen-activated protein kinase 1 [Source:HGNC ...
5595
5595
MAPK3
mitogen-activated protein kinase 3 [Source:HGNC ...
5604
5604
MAP2K1
mitogen-activated protein kinase kinase 1 [Sourc...
5605
5605
MAP2K2
mitogen-activated protein kinase kinase 2 [Sourc...
5894
5894
RAF1
Raf-1 proto-oncogene, serine/threonine kinase [S...
6654
6654
SOS1
SOS Ras/Rac guanine nucleotide exchange factor 1...
6655
6655
SOS2
SOS Ras/Rho guanine nucleotide exchange factor 2...
673
673
BRAF
B-Raf proto-oncogene, serine/threonine kinase [S...
Version history
2024.1.Hs: Updated to network file downloaded on 2024-05-649
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