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Human Gene Set: KEGG_MEDICUS_VARIANT_ERBB2_OVEREXPRESSION_TO_PI3K_SIGNALING_PATHWAY
Standard name
KEGG_MEDICUS_VARIANT_ERBB2_OVEREXPRESSION_TO_PI3K_SIGNALING_PATHWAY
Systematic name
M47393
Brief description
Pathway Definition from KEGG: EGF -> (ERBB2*+EGFR) -> PI3K -> PIP3 -> AKT -> MTOR -> S6K
Full description or abstract
ERBB2-overexpression to PI3K signaling pathway. Pathway ID: N00034. Pathway type: Variant. Pathway class: nt06262 Pancreatic cancer.
Collection
C2: Curated
CP: Canonical Pathways
CP:KEGG_MEDICUS: KEGG Medicus Pathways
Source publication
Exact source
N00034
Related gene sets
External links
https://www.kegg.jp/entry/N00034
Filtered by similarity
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1 similar term(s) from the external resource)
External ID
External Name
N00253
Amplified ERBB2 to PI3K signaling pathway
Source species
Homo sapiens
Contributed by
KEGG (Kyoto Encyclopedia of Genes and Genomes)
Source platform or
identifier namespace
Human_NCBI_Gene_ID
Dataset references
Download gene set
format:
grp
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gmt
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xml
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json
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TSV metadata
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H: Hallmark
C1: Positional
C2: Curated
CGP: Chemical and Genetic Perturbations
CP: Canonical Pathways
CP:BIOCARTA: BioCarta Pathways
CP:KEGG_MEDICUS: KEGG Medicus Pathways
CP:PID: PID Pathways
CP:REACTOME: Reactome Pathways
CP:WIKIPATHWAYS: WikiPathways
CP:KEGG_LEGACY: KEGG Legacy Pathways
C3: Regulatory Target
MIR: microRNA Targets
MIR:MIRDB: miRDB
MIR:MIR_LEGACY: MIR_Legacy
TFT: Transcription Factor Targets
TFT:GTRD: GTRD
TFT:TFT_LEGACY: TFT_Legacy
C4: Computational
3CA: Curated Cancer Cell Atlas gene sets
CGN: Cancer Gene Neighborhoods
CM: Cancer Modules
C5: Ontology
GO: Gene Ontology
GO:BP: GO Biological Process
GO:CC: GO Cellular Component
GO:MF: GO Molecular Function
HPO: Human Phenotype Ontology
C6: Oncogenic Signature
C7: Immunologic Signature
IMMUNESIGDB: ImmuneSigDB
VAX: HIPC Vaccine Response
C8: Cell Type Signature
Compendia expression profiles
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NG-CHM interactive heatmaps
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GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Legacy heatmaps (PNG)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query
Further investigate
these 12 genes
Gene families
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Show members
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12 source identifiers mapped to 12 genes)
Source
Id
NCBI (Entrez)
Gene Id
Gene
Symbol
Gene
Description
10000
10000
AKT3
AKT serine/threonine kinase 3 [Source:HGNC Sy...
1950
1950
EGF
epidermal growth factor [Source:HGNC Symbol;A...
1956
1956
EGFR
epidermal growth factor receptor [Source:HGNC...
2064
2064
ERBB2
erb-b2 receptor tyrosine kinase 2 [Source:HGN...
207
207
AKT1
AKT serine/threonine kinase 1 [Source:HGNC Sy...
208
208
AKT2
AKT serine/threonine kinase 2 [Source:HGNC Sy...
2475
2475
MTOR
mechanistic target of rapamycin kinase [Sourc...
5290
5290
PIK3CA
phosphatidylinositol-4,5-bisphosphate 3-kinas...
5291
5291
PIK3CB
phosphatidylinositol-4,5-bisphosphate 3-kinas...
5293
5293
PIK3CD
phosphatidylinositol-4,5-bisphosphate 3-kinas...
6198
6198
RPS6KB1
ribosomal protein S6 kinase B1 [Source:HGNC S...
6199
6199
RPS6KB2
ribosomal protein S6 kinase B2 [Source:HGNC S...
Version history
2024.1.Hs: Updated to network file downloaded on 2024-05-627
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