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Human Gene Set: KEGG_MEDICUS_REFERENCE_TNF_JNK_SIGNALING_PATHWAY
Standard name
KEGG_MEDICUS_REFERENCE_TNF_JNK_SIGNALING_PATHWAY
Systematic name
M47569
Brief description
Pathway Definition from KEGG: TNF -> TNFRSF1A -> (RIPK1+TRADD+TRAF2/5) -> (TAK1+TAB1/2) -> MKK4/7 -> JNK -> AP1
Full description or abstract
TNF-JNK signaling pathway. Pathway ID: N00446. Pathway type: Reference. Pathway class: nt06516 TNF signaling.
Collection
C2: Curated
CP: Canonical Pathways
CP:KEGG_MEDICUS: KEGG Medicus Pathways
Source publication
Exact source
N00446
Related gene sets
External links
https://www.kegg.jp/entry/N00446
Filtered by similarity
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Source species
Homo sapiens
Contributed by
KEGG (Kyoto Encyclopedia of Genes and Genomes)
Source platform or
identifier namespace
Human_NCBI_Gene_ID
Dataset references
Download gene set
format:
grp
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gmt
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xml
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TSV metadata
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H: Hallmark
C1: Positional
C2: Curated
CGP: Chemical and Genetic Perturbations
CP: Canonical Pathways
CP:BIOCARTA: BioCarta Pathways
CP:KEGG_MEDICUS: KEGG Medicus Pathways
CP:PID: PID Pathways
CP:REACTOME: Reactome Pathways
CP:WIKIPATHWAYS: WikiPathways
CP:KEGG_LEGACY: KEGG Legacy Pathways
C3: Regulatory Target
MIR: microRNA Targets
MIR:MIRDB: miRDB
MIR:MIR_LEGACY: MIR_Legacy
TFT: Transcription Factor Targets
TFT:GTRD: GTRD
TFT:TFT_LEGACY: TFT_Legacy
C4: Computational
3CA: Curated Cancer Cell Atlas gene sets
CGN: Cancer Gene Neighborhoods
CM: Cancer Modules
C5: Ontology
GO: Gene Ontology
GO:BP: GO Biological Process
GO:CC: GO Cellular Component
GO:MF: GO Molecular Function
HPO: Human Phenotype Ontology
C6: Oncogenic Signature
C7: Immunologic Signature
IMMUNESIGDB: ImmuneSigDB
VAX: HIPC Vaccine Response
C8: Cell Type Signature
Compendia expression profiles
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GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Legacy heatmaps (PNG)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query
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these 16 genes
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Show members
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16 source identifiers mapped to 16 genes)
Source
Id
NCBI (Entrez)
Gene Id
Gene
Symbol
Gene
Description
10454
10454
TAB1
TGF-beta activated kinase 1 (MAP3K7) binding...
23118
23118
TAB2
TGF-beta activated kinase 1 (MAP3K7) binding...
2353
2353
FOS
Fos proto-oncogene, AP-1 transcription facto...
3725
3725
JUN
Jun proto-oncogene, AP-1 transcription facto...
5599
5599
MAPK8
mitogen-activated protein kinase 8 [Source:H...
5601
5601
MAPK9
mitogen-activated protein kinase 9 [Source:H...
5602
5602
MAPK10
mitogen-activated protein kinase 10 [Source:...
5609
5609
MAP2K7
mitogen-activated protein kinase kinase 7 [S...
6416
6416
MAP2K4
mitogen-activated protein kinase kinase 4 [S...
6885
6885
MAP3K7
mitogen-activated protein kinase kinase kina...
7124
7124
TNF
tumor necrosis factor [Source:HGNC Symbol;Ac...
7132
7132
TNFRSF1A
TNF receptor superfamily member 1A [Source:H...
7186
7186
TRAF2
TNF receptor associated factor 2 [Source:HGN...
7188
7188
TRAF5
TNF receptor associated factor 5 [Source:HGN...
8717
8717
TRADD
TNFRSF1A associated via death domain [Source...
8737
8737
RIPK1
receptor interacting serine/threonine kinase...
Version history
2024.1.Hs: Updated to network file downloaded on 2024-05-510
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