login
register
GSEA Home
Downloads
Molecular Signatures Database
Documentation
Contact
Team
MSigDB Home
Human Collections
About
Browse
Search
Investigate
Gene Families
Mouse Collections
About
Browse
Search
Investigate
Help
Human Gene Set: KEGG_MEDICUS_REFERENCE_TLR5_NFKB_SIGNALING_PATHWAY
Standard name
KEGG_MEDICUS_REFERENCE_TLR5_NFKB_SIGNALING_PATHWAY
Systematic name
M47912
Brief description
Pathway Definition from KEGG: TLR5 -> (MYD88) -> (IRAK4+IRAK1) -> (TRAF6+TAK1+TAB2) -> IKK -> NFKBIA -> NFKB => (TNF,IL6,IL12A,IL12B)
Full description or abstract
TLR5-NFKB signaling pathway. Pathway ID: N01566. Pathway type: Reference. Pathway class: nt06517 TLR signaling.
Collection
C2: Curated
CP: Canonical Pathways
CP:KEGG_MEDICUS: KEGG Medicus Pathways
Source publication
Exact source
N01566
Related gene sets
External links
https://www.kegg.jp/entry/N01566
Filtered by similarity
?
Source species
Homo sapiens
Contributed by
KEGG (Kyoto Encyclopedia of Genes and Genomes)
Source platform or
identifier namespace
Human_NCBI_Gene_ID
Dataset references
Download gene set
format:
grp
|
gmt
|
xml
|
json
|
TSV metadata
Compute overlaps
?
(
show
collections to investigate for overlap with this gene set)
H: Hallmark
C1: Positional
C2: Curated
CGP: Chemical and Genetic Perturbations
CP: Canonical Pathways
CP:BIOCARTA: BioCarta Pathways
CP:KEGG_MEDICUS: KEGG Medicus Pathways
CP:PID: PID Pathways
CP:REACTOME: Reactome Pathways
CP:WIKIPATHWAYS: WikiPathways
CP:KEGG_LEGACY: KEGG Legacy Pathways
C3: Regulatory Target
MIR: microRNA Targets
MIR:MIRDB: miRDB
MIR:MIR_LEGACY: MIR_Legacy
TFT: Transcription Factor Targets
TFT:GTRD: GTRD
TFT:TFT_LEGACY: TFT_Legacy
C4: Computational
3CA: Curated Cancer Cell Atlas gene sets
CGN: Cancer Gene Neighborhoods
CM: Cancer Modules
C5: Ontology
GO: Gene Ontology
GO:BP: GO Biological Process
GO:CC: GO Cellular Component
GO:MF: GO Molecular Function
HPO: Human Phenotype Ontology
C6: Oncogenic Signature
C7: Immunologic Signature
IMMUNESIGDB: ImmuneSigDB
VAX: HIPC Vaccine Response
C8: Cell Type Signature
Compendia expression profiles
?
NG-CHM interactive heatmaps
(
Please note that clustering takes a few seconds
)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Legacy heatmaps (PNG)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query
Further investigate
these 17 genes
Gene families
?
Categorize
these 17 genes by gene family
Show members
(
show
17 source identifiers mapped to 17 genes)
Source
Id
NCBI (Entrez)
Gene Id
Gene
Symbol
Gene
Description
1147
1147
CHUK
component of inhibitor of nuclear factor kappa...
23118
23118
TAB2
TGF-beta activated kinase 1 (MAP3K7) binding p...
3551
3551
IKBKB
inhibitor of nuclear factor kappa B kinase sub...
3569
3569
IL6
interleukin 6 [Source:HGNC Symbol;Acc:HGNC:6018]
3592
3592
IL12A
interleukin 12A [Source:HGNC Symbol;Acc:HGNC:5...
3593
3593
IL12B
interleukin 12B [Source:HGNC Symbol;Acc:HGNC:5...
3654
3654
IRAK1
interleukin 1 receptor associated kinase 1 [So...
4615
4615
MYD88
MYD88 innate immune signal transduction adapto...
4790
4790
NFKB1
nuclear factor kappa B subunit 1 [Source:HGNC ...
4792
4792
NFKBIA
NFKB inhibitor alpha [Source:HGNC Symbol;Acc:H...
51135
51135
IRAK4
interleukin 1 receptor associated kinase 4 [So...
5970
5970
RELA
RELA proto-oncogene, NF-kB subunit [Source:HGN...
6885
6885
MAP3K7
mitogen-activated protein kinase kinase kinase...
7100
7100
TLR5
toll like receptor 5 [Source:HGNC Symbol;Acc:H...
7124
7124
TNF
tumor necrosis factor [Source:HGNC Symbol;Acc:...
7189
7189
TRAF6
TNF receptor associated factor 6 [Source:HGNC ...
8517
8517
IKBKG
inhibitor of nuclear factor kappa B kinase reg...
Version history
2024.1.Hs: Updated to network file downloaded on 2024-05-506
See
MSigDB license terms here
. Please note that certain gene sets have special access terms.