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Human Gene Set: KEGG_MEDICUS_REFERENCE_TLR4_IRF3_7_SIGNALING_PATHWAY
Standard name
KEGG_MEDICUS_REFERENCE_TLR4_IRF3_7_SIGNALING_PATHWAY
Systematic name
M47598
Brief description
Pathway Definition from KEGG: TLR4 -> TICAM2 -> TICAM1 -> TRAF3 -> (IKBKE+TBK1) -> (IRF3,IRF7) => IFNB1
Full description or abstract
TLR4-IRF3/7 signaling pathway. Pathway ID: N00553. Pathway type: Reference. Pathway class: nt06517 TLR signaling.
Collection
C2: Curated
CP: Canonical Pathways
CP:KEGG_MEDICUS: KEGG Medicus Pathways
Source publication
Exact source
N00553
Related gene sets
External links
https://www.kegg.jp/entry/N00553
Filtered by similarity
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Source species
Homo sapiens
Contributed by
KEGG (Kyoto Encyclopedia of Genes and Genomes)
Source platform or
identifier namespace
Human_NCBI_Gene_ID
Dataset references
Download gene set
format:
grp
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gmt
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xml
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json
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TSV metadata
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H: Hallmark
C1: Positional
C2: Curated
CGP: Chemical and Genetic Perturbations
CP: Canonical Pathways
CP:BIOCARTA: BioCarta Pathways
CP:KEGG_MEDICUS: KEGG Medicus Pathways
CP:PID: PID Pathways
CP:REACTOME: Reactome Pathways
CP:WIKIPATHWAYS: WikiPathways
CP:KEGG_LEGACY: KEGG Legacy Pathways
C3: Regulatory Target
MIR: microRNA Targets
MIR:MIRDB: miRDB
MIR:MIR_LEGACY: MIR_Legacy
TFT: Transcription Factor Targets
TFT:GTRD: GTRD
TFT:TFT_LEGACY: TFT_Legacy
C4: Computational
3CA: Curated Cancer Cell Atlas gene sets
CGN: Cancer Gene Neighborhoods
CM: Cancer Modules
C5: Ontology
GO: Gene Ontology
GO:BP: GO Biological Process
GO:CC: GO Cellular Component
GO:MF: GO Molecular Function
HPO: Human Phenotype Ontology
C6: Oncogenic Signature
C7: Immunologic Signature
IMMUNESIGDB: ImmuneSigDB
VAX: HIPC Vaccine Response
C8: Cell Type Signature
Compendia expression profiles
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GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Legacy heatmaps (PNG)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query
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these 9 genes
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Show members
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9 source identifiers mapped to 9 genes)
Source
Id
NCBI (Entrez)
Gene Id
Gene
Symbol
Gene
Description
148022
148022
TICAM1
TIR domain containing adaptor molecule 1 [So...
29110
29110
TBK1
TANK binding kinase 1 [Source:HGNC Symbol;Ac...
3456
3456
IFNB1
interferon beta 1 [Source:HGNC Symbol;Acc:HG...
353376
353376
TICAM2
TIR domain containing adaptor molecule 2 [So...
3661
3661
IRF3
interferon regulatory factor 3 [Source:HGNC ...
3665
3665
IRF7
interferon regulatory factor 7 [Source:HGNC ...
7099
7099
TLR4
toll like receptor 4 [Source:HGNC Symbol;Acc...
7187
7187
TRAF3
TNF receptor associated factor 3 [Source:HGN...
9641
9641
IKBKE
inhibitor of nuclear factor kappa B kinase s...
Version history
2024.1.Hs: Updated to network file downloaded on 2024-05-504
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