login
register
GSEA Home
Downloads
Molecular Signatures Database
Documentation
Contact
Team
MSigDB Home
Human Collections
About
Browse
Search
Investigate
Gene Families
Mouse Collections
About
Browse
Search
Investigate
Help
Human Gene Set: KEGG_MEDICUS_REFERENCE_NON_CANONICAL_INFLAMMASOME_SIGNALING_PATHWAY
Standard name
KEGG_MEDICUS_REFERENCE_NON_CANONICAL_INFLAMMASOME_SIGNALING_PATHWAY
Systematic name
M47651
Brief description
Pathway Definition from KEGG: LPS -> CASP4/5 -> (NLRP3+PYCARD+CASP1) -> (IL1B,IL18)
Full description or abstract
Non-canonical inflammasome signaling pathway. Pathway ID: N00934. Pathway type: Reference. Pathway class: nt06521 NLR signaling.
Collection
C2: Curated
CP: Canonical Pathways
CP:KEGG_MEDICUS: KEGG Medicus Pathways
Source publication
Exact source
N00934
Related gene sets
External links
https://www.kegg.jp/entry/N00934
Filtered by similarity
?
Source species
Homo sapiens
Contributed by
KEGG (Kyoto Encyclopedia of Genes and Genomes)
Source platform or
identifier namespace
Human_NCBI_Gene_ID
Dataset references
Download gene set
format:
grp
|
gmt
|
xml
|
json
|
TSV metadata
Compute overlaps
?
(
show
collections to investigate for overlap with this gene set)
H: Hallmark
C1: Positional
C2: Curated
CGP: Chemical and Genetic Perturbations
CP: Canonical Pathways
CP:BIOCARTA: BioCarta Pathways
CP:KEGG_MEDICUS: KEGG Medicus Pathways
CP:PID: PID Pathways
CP:REACTOME: Reactome Pathways
CP:WIKIPATHWAYS: WikiPathways
CP:KEGG_LEGACY: KEGG Legacy Pathways
C3: Regulatory Target
MIR: microRNA Targets
MIR:MIRDB: miRDB
MIR:MIR_LEGACY: MIR_Legacy
TFT: Transcription Factor Targets
TFT:GTRD: GTRD
TFT:TFT_LEGACY: TFT_Legacy
C4: Computational
3CA: Curated Cancer Cell Atlas gene sets
CGN: Cancer Gene Neighborhoods
CM: Cancer Modules
C5: Ontology
GO: Gene Ontology
GO:BP: GO Biological Process
GO:CC: GO Cellular Component
GO:MF: GO Molecular Function
HPO: Human Phenotype Ontology
C6: Oncogenic Signature
C7: Immunologic Signature
IMMUNESIGDB: ImmuneSigDB
VAX: HIPC Vaccine Response
C8: Cell Type Signature
Compendia expression profiles
?
NG-CHM interactive heatmaps
(
Please note that clustering takes a few seconds
)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Legacy heatmaps (PNG)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query
Further investigate
these 7 genes
Gene families
?
Categorize
these 7 genes by gene family
Show members
(
show
7 source identifiers mapped to 7 genes)
Source
Id
NCBI (Entrez)
Gene Id
Gene
Symbol
Gene
Description
114548
114548
NLRP3
NLR family pyrin domain containing 3 [Source...
29108
29108
PYCARD
PYD and CARD domain containing [Source:HGNC ...
3553
3553
IL1B
interleukin 1 beta [Source:HGNC Symbol;Acc:H...
3606
3606
IL18
interleukin 18 [Source:HGNC Symbol;Acc:HGNC:...
834
834
CASP1
caspase 1 [Source:HGNC Symbol;Acc:HGNC:1499]
837
837
CASP4
caspase 4 [Source:HGNC Symbol;Acc:HGNC:1505]
838
838
CASP5
caspase 5 [Source:HGNC Symbol;Acc:HGNC:1506]
Version history
2024.1.Hs: Updated to network file downloaded on 2024-05-568
See
MSigDB license terms here
. Please note that certain gene sets have special access terms.