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Human Gene Set: KEGG_MEDICUS_REFERENCE_INTRINSIC_APOPTOTIC_PATHWAY
Standard name
KEGG_MEDICUS_REFERENCE_INTRINSIC_APOPTOTIC_PATHWAY
Systematic name
M47434
Brief description
Pathway Definition from KEGG: (PMAIP1,BBC3,BAD,BCL2L11) -| (BCL2,BCL2L1) -| (BAX,BAK1) -> CYCS == APAF1 -> CASP9 -> (CASP3,CASP7)
Full description or abstract
Intrinsic apoptotic pathway. Pathway ID: N00098. Pathway type: Reference. Pathway class: nt06524 Apoptosis.
Collection
C2: Curated
CP: Canonical Pathways
CP:KEGG_MEDICUS: KEGG Medicus Pathways
Source publication
Exact source
N00098
Related gene sets
External links
https://www.kegg.jp/entry/N00098
Filtered by similarity
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Source species
Homo sapiens
Contributed by
KEGG (Kyoto Encyclopedia of Genes and Genomes)
Source platform or
identifier namespace
Human_NCBI_Gene_ID
Dataset references
Download gene set
format:
grp
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gmt
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xml
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json
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TSV metadata
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H: Hallmark
C1: Positional
C2: Curated
CGP: Chemical and Genetic Perturbations
CP: Canonical Pathways
CP:BIOCARTA: BioCarta Pathways
CP:KEGG_MEDICUS: KEGG Medicus Pathways
CP:PID: PID Pathways
CP:REACTOME: Reactome Pathways
CP:WIKIPATHWAYS: WikiPathways
CP:KEGG_LEGACY: KEGG Legacy Pathways
C3: Regulatory Target
MIR: microRNA Targets
MIR:MIRDB: miRDB
MIR:MIR_LEGACY: MIR_Legacy
TFT: Transcription Factor Targets
TFT:GTRD: GTRD
TFT:TFT_LEGACY: TFT_Legacy
C4: Computational
3CA: Curated Cancer Cell Atlas gene sets
CGN: Cancer Gene Neighborhoods
CM: Cancer Modules
C5: Ontology
GO: Gene Ontology
GO:BP: GO Biological Process
GO:CC: GO Cellular Component
GO:MF: GO Molecular Function
HPO: Human Phenotype Ontology
C6: Oncogenic Signature
C7: Immunologic Signature
IMMUNESIGDB: ImmuneSigDB
VAX: HIPC Vaccine Response
C8: Cell Type Signature
Compendia expression profiles
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NG-CHM interactive heatmaps
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GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Legacy heatmaps (PNG)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query
Further investigate
these 13 genes
Gene families
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these 13 genes by gene family
Show members
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13 source identifiers mapped to 13 genes)
Source
Id
NCBI (Entrez)
Gene Id
Gene
Symbol
Gene
Description
10018
10018
BCL2L11
BCL2 like 11 [Source:HGNC Symbol;Acc:HGNC:994]
27113
27113
BBC3
BCL2 binding component 3 [Source:HGNC Symbol;...
317
317
APAF1
apoptotic peptidase activating factor 1 [Sour...
5366
5366
PMAIP1
phorbol-12-myristate-13-acetate-induced prote...
54205
54205
CYCS
cytochrome c, somatic [Source:HGNC Symbol;Acc...
572
572
BAD
BCL2 associated agonist of cell death [Source...
578
578
BAK1
BCL2 antagonist/killer 1 [Source:HGNC Symbol;...
581
581
BAX
BCL2 associated X, apoptosis regulator [Sourc...
596
596
BCL2
BCL2 apoptosis regulator [Source:HGNC Symbol;...
598
598
BCL2L1
BCL2 like 1 [Source:HGNC Symbol;Acc:HGNC:992]
836
836
CASP3
caspase 3 [Source:HGNC Symbol;Acc:HGNC:1504]
840
840
CASP7
caspase 7 [Source:HGNC Symbol;Acc:HGNC:1508]
842
842
CASP9
caspase 9 [Source:HGNC Symbol;Acc:HGNC:1511]
Version history
2024.1.Hs: Updated to network file downloaded on 2024-05-363
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