login
register
GSEA Home
Downloads
Molecular Signatures Database
Documentation
Contact
Team
MSigDB Home
Human Collections
About
Browse
Search
Investigate
Gene Families
Mouse Collections
About
Browse
Search
Investigate
Help
Human Gene Set: KEGG_MEDICUS_REFERENCE_IL12_23_TO_JAK_STAT_SIGNALING_PATHWAY
Standard name
KEGG_MEDICUS_REFERENCE_IL12_23_TO_JAK_STAT_SIGNALING_PATHWAY
Systematic name
M47907
Brief description
Pathway Definition from KEGG: (IL12,IL23A) -> ((IL12RB1+IL12RB2),(IL12RB1+IL23R)) -> (JAK2+TYK2) -> (STAT3,STAT4)
Full description or abstract
IL12/23 to Jak-STAT signaling pathway. Pathway ID: N01557. Pathway type: Reference. Pathway class: nt06518 JAK-STAT signaling.
Collection
C2: Curated
CP: Canonical Pathways
CP:KEGG_MEDICUS: KEGG Medicus Pathways
Source publication
Exact source
N01557
Related gene sets
External links
https://www.kegg.jp/entry/N01557
Filtered by similarity
?
Source species
Homo sapiens
Contributed by
KEGG (Kyoto Encyclopedia of Genes and Genomes)
Source platform or
identifier namespace
Human_NCBI_Gene_ID
Dataset references
Download gene set
format:
grp
|
gmt
|
xml
|
json
|
TSV metadata
Compute overlaps
?
(
show
collections to investigate for overlap with this gene set)
H: Hallmark
C1: Positional
C2: Curated
CGP: Chemical and Genetic Perturbations
CP: Canonical Pathways
CP:BIOCARTA: BioCarta Pathways
CP:KEGG_MEDICUS: KEGG Medicus Pathways
CP:PID: PID Pathways
CP:REACTOME: Reactome Pathways
CP:WIKIPATHWAYS: WikiPathways
CP:KEGG_LEGACY: KEGG Legacy Pathways
C3: Regulatory Target
MIR: microRNA Targets
MIR:MIRDB: miRDB
MIR:MIR_LEGACY: MIR_Legacy
TFT: Transcription Factor Targets
TFT:GTRD: GTRD
TFT:TFT_LEGACY: TFT_Legacy
C4: Computational
3CA: Curated Cancer Cell Atlas gene sets
CGN: Cancer Gene Neighborhoods
CM: Cancer Modules
C5: Ontology
GO: Gene Ontology
GO:BP: GO Biological Process
GO:CC: GO Cellular Component
GO:MF: GO Molecular Function
HPO: Human Phenotype Ontology
C6: Oncogenic Signature
C7: Immunologic Signature
IMMUNESIGDB: ImmuneSigDB
VAX: HIPC Vaccine Response
C8: Cell Type Signature
Compendia expression profiles
?
NG-CHM interactive heatmaps
(
Please note that clustering takes a few seconds
)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Legacy heatmaps (PNG)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query
Further investigate
these 10 genes
Gene families
?
Categorize
these 10 genes by gene family
Show members
(
show
10 source identifiers mapped to 10 genes)
Source
Id
NCBI (Entrez)
Gene Id
Gene
Symbol
Gene
Description
149233
149233
IL23R
interleukin 23 receptor [Source:HGNC Symbol...
3592
3592
IL12A
interleukin 12A [Source:HGNC Symbol;Acc:HGN...
3593
3593
IL12B
interleukin 12B [Source:HGNC Symbol;Acc:HGN...
3594
3594
IL12RB1
interleukin 12 receptor subunit beta 1 [Sou...
3595
3595
IL12RB2
interleukin 12 receptor subunit beta 2 [Sou...
3717
3717
JAK2
Janus kinase 2 [Source:HGNC Symbol;Acc:HGNC...
51561
51561
IL23A
interleukin 23 subunit alpha [Source:HGNC S...
6774
6774
STAT3
signal transducer and activator of transcri...
6775
6775
STAT4
signal transducer and activator of transcri...
7297
7297
TYK2
tyrosine kinase 2 [Source:HGNC Symbol;Acc:H...
Version history
2024.1.Hs: Updated to network file downloaded on 2024-05-276
See
MSigDB license terms here
. Please note that certain gene sets have special access terms.