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Human Gene Set: KEGG_MEDICUS_REFERENCE_EXTRINSIC_APOPTOTIC_PATHWAY
Standard name
KEGG_MEDICUS_REFERENCE_EXTRINSIC_APOPTOTIC_PATHWAY
Systematic name
M47447
Brief description
Pathway Definition from KEGG: TNF -> TNFRSF1A -> (RIPK1+TRADD+TRAF2/5) -> FADD -> CASP8 -> (CASP3,CASP7)
Full description or abstract
Extrinsic apoptotic pathway. Pathway ID: N00145. Pathway type: Reference. Pathway class: nt06516 TNF signaling.
Collection
C2: Curated
CP: Canonical Pathways
CP:KEGG_MEDICUS: KEGG Medicus Pathways
Source publication
Exact source
N00145
Related gene sets
External links
https://www.kegg.jp/entry/N00145
Filtered by similarity
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Source species
Homo sapiens
Contributed by
KEGG (Kyoto Encyclopedia of Genes and Genomes)
Source platform or
identifier namespace
Human_NCBI_Gene_ID
Dataset references
Download gene set
format:
grp
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gmt
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xml
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json
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TSV metadata
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H: Hallmark
C1: Positional
C2: Curated
CGP: Chemical and Genetic Perturbations
CP: Canonical Pathways
CP:BIOCARTA: BioCarta Pathways
CP:KEGG_MEDICUS: KEGG Medicus Pathways
CP:PID: PID Pathways
CP:REACTOME: Reactome Pathways
CP:WIKIPATHWAYS: WikiPathways
CP:KEGG_LEGACY: KEGG Legacy Pathways
C3: Regulatory Target
MIR: microRNA Targets
MIR:MIRDB: miRDB
MIR:MIR_LEGACY: MIR_Legacy
TFT: Transcription Factor Targets
TFT:GTRD: GTRD
TFT:TFT_LEGACY: TFT_Legacy
C4: Computational
3CA: Curated Cancer Cell Atlas gene sets
CGN: Cancer Gene Neighborhoods
CM: Cancer Modules
C5: Ontology
GO: Gene Ontology
GO:BP: GO Biological Process
GO:CC: GO Cellular Component
GO:MF: GO Molecular Function
HPO: Human Phenotype Ontology
C6: Oncogenic Signature
C7: Immunologic Signature
IMMUNESIGDB: ImmuneSigDB
VAX: HIPC Vaccine Response
C8: Cell Type Signature
Compendia expression profiles
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NG-CHM interactive heatmaps
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GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Legacy heatmaps (PNG)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query
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Show members
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10 source identifiers mapped to 10 genes)
Source
Id
NCBI (Entrez)
Gene Id
Gene
Symbol
Gene
Description
7124
7124
TNF
tumor necrosis factor [Source:HGNC Symbol;Acc:...
7132
7132
TNFRSF1A
TNF receptor superfamily member 1A [Source:HGN...
7186
7186
TRAF2
TNF receptor associated factor 2 [Source:HGNC ...
7188
7188
TRAF5
TNF receptor associated factor 5 [Source:HGNC ...
836
836
CASP3
caspase 3 [Source:HGNC Symbol;Acc:HGNC:1504]
840
840
CASP7
caspase 7 [Source:HGNC Symbol;Acc:HGNC:1508]
841
841
CASP8
caspase 8 [Source:HGNC Symbol;Acc:HGNC:1509]
8717
8717
TRADD
TNFRSF1A associated via death domain [Source:H...
8737
8737
RIPK1
receptor interacting serine/threonine kinase 1...
8772
8772
FADD
Fas associated via death domain [Source:HGNC S...
Version history
2024.1.Hs: Updated to network file downloaded on 2024-05-511
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