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Human Gene Set: KEGG_MEDICUS_REFERENCE_EGF_EGFR_RAS_JNK_SIGNALING_PATHWAY
Standard name
KEGG_MEDICUS_REFERENCE_EGF_EGFR_RAS_JNK_SIGNALING_PATHWAY
Systematic name
M47594
Brief description
Pathway Definition from KEGG: EGF -> EGFR -> GRB2 -> SOS -> RAS -> MEKK1 -> MKK4 -> JNK
Full description or abstract
EGF-EGFR-RAS-JNK signaling pathway. Pathway ID: N00542. Pathway type: Reference. Pathway class: nt06526 MAPK signaling.
Collection
C2: Curated
CP: Canonical Pathways
CP:KEGG_MEDICUS: KEGG Medicus Pathways
Source publication
Exact source
N00542
Related gene sets
External links
https://www.kegg.jp/entry/N00542
Filtered by similarity
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Source species
Homo sapiens
Contributed by
KEGG (Kyoto Encyclopedia of Genes and Genomes)
Source platform or
identifier namespace
Human_NCBI_Gene_ID
Dataset references
Download gene set
format:
grp
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gmt
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xml
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json
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TSV metadata
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H: Hallmark
C1: Positional
C2: Curated
CGP: Chemical and Genetic Perturbations
CP: Canonical Pathways
CP:BIOCARTA: BioCarta Pathways
CP:KEGG_MEDICUS: KEGG Medicus Pathways
CP:PID: PID Pathways
CP:REACTOME: Reactome Pathways
CP:WIKIPATHWAYS: WikiPathways
CP:KEGG_LEGACY: KEGG Legacy Pathways
C3: Regulatory Target
MIR: microRNA Targets
MIR:MIRDB: miRDB
MIR:MIR_LEGACY: MIR_Legacy
TFT: Transcription Factor Targets
TFT:GTRD: GTRD
TFT:TFT_LEGACY: TFT_Legacy
C4: Computational
3CA: Curated Cancer Cell Atlas gene sets
CGN: Cancer Gene Neighborhoods
CM: Cancer Modules
C5: Ontology
GO: Gene Ontology
GO:BP: GO Biological Process
GO:CC: GO Cellular Component
GO:MF: GO Molecular Function
HPO: Human Phenotype Ontology
C6: Oncogenic Signature
C7: Immunologic Signature
IMMUNESIGDB: ImmuneSigDB
VAX: HIPC Vaccine Response
C8: Cell Type Signature
Compendia expression profiles
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GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Legacy heatmaps (PNG)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query
Further investigate
these 13 genes
Gene families
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these 13 genes by gene family
Show members
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13 source identifiers mapped to 13 genes)
Source
Id
NCBI (Entrez)
Gene Id
Gene
Symbol
Gene
Description
1950
1950
EGF
epidermal growth factor [Source:HGNC Symbol;Acc:...
1956
1956
EGFR
epidermal growth factor receptor [Source:HGNC Sy...
2885
2885
GRB2
growth factor receptor bound protein 2 [Source:H...
3265
3265
HRAS
HRas proto-oncogene, GTPase [Source:HGNC Symbol;...
3845
3845
KRAS
KRAS proto-oncogene, GTPase [Source:HGNC Symbol;...
4214
4214
MAP3K1
mitogen-activated protein kinase kinase kinase 1...
4893
4893
NRAS
NRAS proto-oncogene, GTPase [Source:HGNC Symbol;...
5599
5599
MAPK8
mitogen-activated protein kinase 8 [Source:HGNC ...
5601
5601
MAPK9
mitogen-activated protein kinase 9 [Source:HGNC ...
5602
5602
MAPK10
mitogen-activated protein kinase 10 [Source:HGNC...
6416
6416
MAP2K4
mitogen-activated protein kinase kinase 4 [Sourc...
6654
6654
SOS1
SOS Ras/Rac guanine nucleotide exchange factor 1...
6655
6655
SOS2
SOS Ras/Rho guanine nucleotide exchange factor 2...
Version history
2024.1.Hs: Updated to network file downloaded on 2024-05-101
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