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Human Gene Set: KEGG_MEDICUS_REFERENCE_EGF_EGFR_PI3K_NFKB_SIGNALING_PATHWAY
Standard name
KEGG_MEDICUS_REFERENCE_EGF_EGFR_PI3K_NFKB_SIGNALING_PATHWAY
Systematic name
M47536
Brief description
Pathway Definition from KEGG: EGF -> EGFR -> PI3K -> PIP3 -> AKT -> IKK -> NFKBIA -> NFKB
Full description or abstract
EGF-EGFR-PI3K-NFKB signaling pathway. Pathway ID: N00390. Pathway type: Reference. Pathway class: nt06214 PI3K signaling.
Collection
C2: Curated
CP: Canonical Pathways
CP:KEGG_MEDICUS: KEGG Medicus Pathways
Source publication
Exact source
N00390
Related gene sets
External links
https://www.kegg.jp/entry/N00390
Filtered by similarity
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Source species
Homo sapiens
Contributed by
KEGG (Kyoto Encyclopedia of Genes and Genomes)
Source platform or
identifier namespace
Human_NCBI_Gene_ID
Dataset references
Download gene set
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grp
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gmt
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TSV metadata
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H: Hallmark
C1: Positional
C2: Curated
CGP: Chemical and Genetic Perturbations
CP: Canonical Pathways
CP:BIOCARTA: BioCarta Pathways
CP:KEGG_MEDICUS: KEGG Medicus Pathways
CP:PID: PID Pathways
CP:REACTOME: Reactome Pathways
CP:WIKIPATHWAYS: WikiPathways
CP:KEGG_LEGACY: KEGG Legacy Pathways
C3: Regulatory Target
MIR: microRNA Targets
MIR:MIRDB: miRDB
MIR:MIR_LEGACY: MIR_Legacy
TFT: Transcription Factor Targets
TFT:GTRD: GTRD
TFT:TFT_LEGACY: TFT_Legacy
C4: Computational
3CA: Curated Cancer Cell Atlas gene sets
CGN: Cancer Gene Neighborhoods
CM: Cancer Modules
C5: Ontology
GO: Gene Ontology
GO:BP: GO Biological Process
GO:CC: GO Cellular Component
GO:MF: GO Molecular Function
HPO: Human Phenotype Ontology
C6: Oncogenic Signature
C7: Immunologic Signature
IMMUNESIGDB: ImmuneSigDB
VAX: HIPC Vaccine Response
C8: Cell Type Signature
Compendia expression profiles
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GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Legacy heatmaps (PNG)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query
Further investigate
these 14 genes
Gene families
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Show members
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14 source identifiers mapped to 14 genes)
Source
Id
NCBI (Entrez)
Gene Id
Gene
Symbol
Gene
Description
10000
10000
AKT3
AKT serine/threonine kinase 3 [Source:HGNC Sym...
1147
1147
CHUK
component of inhibitor of nuclear factor kappa...
1950
1950
EGF
epidermal growth factor [Source:HGNC Symbol;Ac...
1956
1956
EGFR
epidermal growth factor receptor [Source:HGNC ...
207
207
AKT1
AKT serine/threonine kinase 1 [Source:HGNC Sym...
208
208
AKT2
AKT serine/threonine kinase 2 [Source:HGNC Sym...
3551
3551
IKBKB
inhibitor of nuclear factor kappa B kinase sub...
4790
4790
NFKB1
nuclear factor kappa B subunit 1 [Source:HGNC ...
4792
4792
NFKBIA
NFKB inhibitor alpha [Source:HGNC Symbol;Acc:H...
5290
5290
PIK3CA
phosphatidylinositol-4,5-bisphosphate 3-kinase...
5291
5291
PIK3CB
phosphatidylinositol-4,5-bisphosphate 3-kinase...
5293
5293
PIK3CD
phosphatidylinositol-4,5-bisphosphate 3-kinase...
5970
5970
RELA
RELA proto-oncogene, NF-kB subunit [Source:HGN...
8517
8517
IKBKG
inhibitor of nuclear factor kappa B kinase reg...
Version history
2024.1.Hs: Updated to network file downloaded on 2024-05-106
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