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Human Gene Set: KEGG_MEDICUS_REFERENCE_DOUBLE_STRAND_BREAK_SIGNALING
Standard name
KEGG_MEDICUS_REFERENCE_DOUBLE_STRAND_BREAK_SIGNALING
Systematic name
M47832
Brief description
Pathway Definition from KEGG: MRN == ATM == H2AX -> MRN+ATM+MDC1+H2AX == RNF8+HERC2+UBE2V2+UBE2N -> MRN+ATM+RNF8+MDC1+H2AX == L3MBTL2 == RNF168+UBE2V2+UBE2N+HERC2 == PIAS4
Full description or abstract
Double-strand break signaling. Pathway ID: N01439. Pathway type: Reference. Pathway class: nt06506 Double-strand break repair.
Collection
C2: Curated
CP: Canonical Pathways
CP:KEGG_MEDICUS: KEGG Medicus Pathways
Source publication
Exact source
N01439
Related gene sets
External links
https://www.kegg.jp/entry/N01439
Filtered by similarity
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Source species
Homo sapiens
Contributed by
KEGG (Kyoto Encyclopedia of Genes and Genomes)
Source platform or
identifier namespace
Human_NCBI_Gene_ID
Dataset references
Download gene set
format:
grp
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gmt
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xml
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json
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TSV metadata
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H: Hallmark
C1: Positional
C2: Curated
CGP: Chemical and Genetic Perturbations
CP: Canonical Pathways
CP:BIOCARTA: BioCarta Pathways
CP:KEGG_MEDICUS: KEGG Medicus Pathways
CP:PID: PID Pathways
CP:REACTOME: Reactome Pathways
CP:WIKIPATHWAYS: WikiPathways
CP:KEGG_LEGACY: KEGG Legacy Pathways
C3: Regulatory Target
MIR: microRNA Targets
MIR:MIRDB: miRDB
MIR:MIR_LEGACY: MIR_Legacy
TFT: Transcription Factor Targets
TFT:GTRD: GTRD
TFT:TFT_LEGACY: TFT_Legacy
C4: Computational
3CA: Curated Cancer Cell Atlas gene sets
CGN: Cancer Gene Neighborhoods
CM: Cancer Modules
C5: Ontology
GO: Gene Ontology
GO:BP: GO Biological Process
GO:CC: GO Cellular Component
GO:MF: GO Molecular Function
HPO: Human Phenotype Ontology
C6: Oncogenic Signature
C7: Immunologic Signature
IMMUNESIGDB: ImmuneSigDB
VAX: HIPC Vaccine Response
C8: Cell Type Signature
Compendia expression profiles
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GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Legacy heatmaps (PNG)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query
Further investigate
these 13 genes
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Show members
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13 source identifiers mapped to 13 genes)
Source
Id
NCBI (Entrez)
Gene Id
Gene
Symbol
Gene
Description
10111
10111
RAD50
RAD50 double strand break repair protein [S...
165918
165918
RNF168
ring finger protein 168 [Source:HGNC Symbol...
3014
3014
H2AX
H2A.X variant histone [Source:HGNC Symbol;A...
4361
4361
MRE11
MRE11 homolog, double strand break repair n...
4683
4683
NBN
nibrin [Source:HGNC Symbol;Acc:HGNC:7652]
472
472
ATM
ATM serine/threonine kinase [Source:HGNC Sy...
51588
51588
PIAS4
protein inhibitor of activated STAT 4 [Sour...
7334
7334
UBE2N
ubiquitin conjugating enzyme E2 N [Source:H...
7336
7336
UBE2V2
ubiquitin conjugating enzyme E2 V2 [Source:...
83746
83746
L3MBTL2
L3MBTL histone methyl-lysine binding protei...
8924
8924
HERC2
HECT and RLD domain containing E3 ubiquitin...
9025
9025
RNF8
ring finger protein 8 [Source:HGNC Symbol;A...
9656
9656
MDC1
mediator of DNA damage checkpoint 1 [Source...
Version history
2024.1.Hs: Updated to network file downloaded on 2024-05-309
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