login
register
GSEA Home
Downloads
Molecular Signatures Database
Documentation
Contact
Team
MSigDB Home
Human Collections
About
Browse
Search
Investigate
Gene Families
Mouse Collections
About
Browse
Search
Investigate
Help
Human Gene Set: KEGG_MEDICUS_ENV_FACTOR_METALS_TO_RAS_ERK_SIGNALING_PATHWAY
Standard name
KEGG_MEDICUS_ENV_FACTOR_METALS_TO_RAS_ERK_SIGNALING_PATHWAY
Systematic name
M47815
Brief description
Pathway Definition from KEGG: Metals -> ROS -> RAS -> RAF -> MEK -> ERK -> AP1
Full description or abstract
Metals to RAS-ERK signaling pathway. Pathway ID: N01408. Pathway type: Env factor. Pathway class: nt06210 ERK signaling.
Collection
C2: Curated
CP: Canonical Pathways
CP:KEGG_MEDICUS: KEGG Medicus Pathways
Source publication
Exact source
N01408
Related gene sets
External links
https://www.kegg.jp/entry/N01408
Filtered by similarity
?
Source species
Homo sapiens
Contributed by
KEGG (Kyoto Encyclopedia of Genes and Genomes)
Source platform or
identifier namespace
Human_NCBI_Gene_ID
Dataset references
Download gene set
format:
grp
|
gmt
|
xml
|
json
|
TSV metadata
Compute overlaps
?
(
show
collections to investigate for overlap with this gene set)
H: Hallmark
C1: Positional
C2: Curated
CGP: Chemical and Genetic Perturbations
CP: Canonical Pathways
CP:BIOCARTA: BioCarta Pathways
CP:KEGG_MEDICUS: KEGG Medicus Pathways
CP:PID: PID Pathways
CP:REACTOME: Reactome Pathways
CP:WIKIPATHWAYS: WikiPathways
CP:KEGG_LEGACY: KEGG Legacy Pathways
C3: Regulatory Target
MIR: microRNA Targets
MIR:MIRDB: miRDB
MIR:MIR_LEGACY: MIR_Legacy
TFT: Transcription Factor Targets
TFT:GTRD: GTRD
TFT:TFT_LEGACY: TFT_Legacy
C4: Computational
3CA: Curated Cancer Cell Atlas gene sets
CGN: Cancer Gene Neighborhoods
CM: Cancer Modules
C5: Ontology
GO: Gene Ontology
GO:BP: GO Biological Process
GO:CC: GO Cellular Component
GO:MF: GO Molecular Function
HPO: Human Phenotype Ontology
C6: Oncogenic Signature
C7: Immunologic Signature
IMMUNESIGDB: ImmuneSigDB
VAX: HIPC Vaccine Response
C8: Cell Type Signature
Compendia expression profiles
?
NG-CHM interactive heatmaps
(
Please note that clustering takes a few seconds
)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Legacy heatmaps (PNG)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query
Further investigate
these 12 genes
Gene families
?
Categorize
these 12 genes by gene family
Show members
(
show
12 source identifiers mapped to 12 genes)
Source
Id
NCBI (Entrez)
Gene Id
Gene
Symbol
Gene
Description
2353
2353
FOS
Fos proto-oncogene, AP-1 transcription factor su...
3265
3265
HRAS
HRas proto-oncogene, GTPase [Source:HGNC Symbol;...
369
369
ARAF
A-Raf proto-oncogene, serine/threonine kinase [S...
3725
3725
JUN
Jun proto-oncogene, AP-1 transcription factor su...
3845
3845
KRAS
KRAS proto-oncogene, GTPase [Source:HGNC Symbol;...
4893
4893
NRAS
NRAS proto-oncogene, GTPase [Source:HGNC Symbol;...
5594
5594
MAPK1
mitogen-activated protein kinase 1 [Source:HGNC ...
5595
5595
MAPK3
mitogen-activated protein kinase 3 [Source:HGNC ...
5604
5604
MAP2K1
mitogen-activated protein kinase kinase 1 [Sourc...
5605
5605
MAP2K2
mitogen-activated protein kinase kinase 2 [Sourc...
5894
5894
RAF1
Raf-1 proto-oncogene, serine/threonine kinase [S...
673
673
BRAF
B-Raf proto-oncogene, serine/threonine kinase [S...
Version history
2024.1.Hs: Updated to network file downloaded on 2024-05-236
See
MSigDB license terms here
. Please note that certain gene sets have special access terms.