Human Gene Set: KEGG_HEMATOPOIETIC_CELL_LINEAGE


Standard name KEGG_HEMATOPOIETIC_CELL_LINEAGE
Systematic name M6856
Brief description Hematopoietic cell lineage
Full description or abstract Blood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid progenitor (CLP) or a common myeloid progenitor (CMP). A CLP gives rise to the lymphoid lineage of white blood cells or leukocytes-the natural killer (NK) cells and the T and B lymphocytes. A CMP gives rise to the myeloid lineage, which comprises the rest of the leukocytes, the erythrocytes (red blood cells), and the megakaryocytes that produce platelets important in blood clotting. Cells undergoing these differentiation process express a stage- and lineage-specific set of surface markers. Therefore cellular stages are identified by the specific expression patterns of these genes.
Collection C2: Curated
      CP: Canonical Pathways
            CP:KEGG_LEGACY: KEGG Legacy Pathways
Source publication  
Exact source hsa04640
Related gene sets  
External links http://www.genome.jp/pathway/hsa04640
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Source species Homo sapiens
Contributed by KEGG (Kyoto Encyclopedia of Genes and Genomes)
Source platform or
identifier namespace		 Human_NCBI_Gene_ID
Dataset references  
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GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
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Version history  

The content of the gene sets in the KEGG_LEGACY collection has not been updated since KEGG restricted their usage terms in 2011. More recent sets are available in the KEGG_MEDICUS collection, derived from KEGG's openly available MEDICUS subset.



License Terms for Legacy KEGG data in MSigDB

MSigDB gene sets derived from Legacy KEGG pathways are protected by copyright, (c) 1995-2017 Kanehisa Laboratories, all rights reserved. They are provided for use in the MSigDB collection under license to the Broad Institute, Inc., with qualified permission to include in this release. End users are directed to http://www.pathway.jp/ and http://www.kegg.jp/kegg/docs/plea.html for information on the copyright holder's academic and commercial licensing policies. Inclusion of these gene sets herein is conditioned upon acknowledgment and retention of the aforementioned copyright, and compliance with such policies. These KEGG derived gene sets are in a subcollection MSigDB C2 named "KEGG_LEGACY", and can be recognized by the "KEGG_" prefix (without "MEDICUS") in their name.

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