Human Gene Set: KANG_FLUOROURACIL_RESISTANCE_DN


Standard name KANG_FLUOROURACIL_RESISTANCE_DN
Systematic name M12110
Brief description Genes down-regulated in gastric cancer cell lines resistant to 5-fluorouracil [PubChem=3385].
Full description or abstract PURPOSE: A major obstacle in chemotherapy is treatment failure due to anticancer drug resistance. The emergence of acquired resistance results from host factors and genetic or epigenetic changes in the cancer cells. The purpose of this study was to identify differentially expressed genes associated with acquisition of resistance in human gastric cancer cells. EXPERIMENTAL DESIGN: We performed global gene expression analysis in the acquired drug-resistant gastric cancer cell lines to the commonly used drugs 5-fluorouracil, doxorubicin, and cisplatin using Affymetrix HG-U133A microarray. The gene expression patterns of 10 chemoresistant gastric cancer cell lines were compared with those of four parent cell lines using fold-change and Wilcoxon's test for data analysis. RESULTS: We identified over 250 genes differentially expressed in 5-fluorouracil-, cisplatin-, or doxorubicin-resistant gastric cancer cell lines. Our expression analysis also identified eight multidrug resistance candidate genes that were associated with resistance to two or more of the tested chemotherapeutic agents. Among these, midkine (MDK), a heparin-binding growth factor, was overexpressed in all drug-resistant cell lines, strongly suggesting that MDK might contribute to multidrug resistance in gastric cancer cells. CONCLUSIONS: Our investigation provides comprehensive gene information associated with acquired resistance to anticancer drugs in gastric cancer cells and a basis for additional functional studies.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 14734480   Authors: Kang HC,Kim IJ,Park JH,Shin Y,Ku JL,Jung MS,Yoo BC,Kim HK,Park JG
Exact source Table 2, 2A
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Source species Homo sapiens
Contributed by John Newman (University of Washington)
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identifier namespace		 AFFY_HG_U133
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Version history 3.0: Renamed from 5FU_RESIST_GASTRIC_DN

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