Human Gene Set: JONES_OVARY_STROMAL


Standard name JONES_OVARY_STROMAL
Systematic name M48352
Brief description Marker genes selected by filtering the centroid data for genes with a value > 0 for the given cell type
Full description or abstract The reproductive and endocrine functions of the ovary involve spatially defined interactions among specialized cell populations. Despite the ovary's importance in fertility and endocrine health, functional attributes of ovarian cells are largely uncharacterized. Here, we profiled >18,000 genes in 257 regions from the ovaries of two premenopausal donors to examine the functional units in the ovary. We also generated single-cell RNA sequencing data for 21,198 cells from three additional donors and identified four major cell types and four immune cell subtypes. Custom selection of sampling areas revealed distinct gene activities for oocytes, theca, and granulosa cells. These data contributed panels of oocyte-, theca-, and granulosa-specific genes, thus expanding the knowledge of molecular programs driving follicle development. Serial samples around oocytes and across the cortex and medulla uncovered previously unappreciated variation of hormone and extracellular matrix remodeling activities. This combined spatial and single-cell atlas serves as a resource for future studies of rare cells and pathological states in the ovary.
Collection C8: Cell Type Signature
Source publication Pubmed 38578993   Authors: Jones ASK,Hannum DF,Machlin JH,Tan A,Ma Q,Ulrich ND,Shen YC,Ciarelli M,Padmanabhan V,Marsh EE,Hammoud S,Li JZ,Shikanov A
Exact source adm7506_Data_S8: Stromal > 0
Related gene sets (show 9 additional gene sets from the source publication)

(show 12 gene sets from the same authors)
External links
Filtered by similarity ?
Source species Homo sapiens
Contributed by Anthony Castanza (MSigDB Team)
Source platform or
identifier namespace		 HUMAN_GENE_SYMBOL
Dataset references  
Download gene set format: grp | gmt | xml | json | TSV metadata
Compute overlaps ? (show collections to investigate for overlap with this gene set)
Compendia expression profiles ? NG-CHM interactive heatmaps
(Please note that clustering takes a few seconds)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)

Legacy heatmaps (PNG)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query Further investigate these 156 genes
Gene families ? Categorize these 156 genes by gene family
Show members (show 157 source identifiers mapped to 156 genes)
Version history 2024.1.Hs: First Introduced.

See MSigDB license terms here. Please note that certain gene sets have special access terms.