Human Gene Set: JOHNSTONE_PARVB_TARGETS_2_DN


Standard name JOHNSTONE_PARVB_TARGETS_2_DN
Systematic name M2239
Brief description Genes down-regulated upon overexpression of PARVB [GeneID=29780] in MDA-MB-231 cells (breast cancer) cultured in 3D collagen I and 3D Matrigel only.
Full description or abstract Parvin-beta is a focal adhesion protein downregulated in human breast cancer cells. Loss of Parvin-beta contributes to increased integrin-linked kinase activity, cell-matrix adhesion, and invasion through the extracellular matrix in vitro. The effect of ectopic Parvin-beta expression on the transcriptional profile of MDA-MB-231 breast cancer cells, which normally do not express Parvin-beta, was evaluated. Particular emphasis was placed upon propagating MDA-MB-231 breast cancer cells in three-dimensional culture matrices. Interestingly, Parvin-beta reexpression in MDA-MB-231 cells increased the mRNA expression, serine 82 phosphorylation (mediated by CDK9), and activity of the nuclear hormone receptor peroxisome proliferator-activated receptor gamma (PPARgamma), and there was a concomitant increase in lipogenic gene expression as a downstream effector of PPARgamma. Importantly, Parvin-beta suppressed breast cancer growth in vivo, with associated decreased proliferation. These data suggest that Parvin-beta might influence breast cancer progression.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 17998334   Authors: Johnstone CN,Mongroo PS,Rich AS,Schupp M,Bowser MJ,Delemos AS,Tobias JW,Liu Y,Hannigan GE,Rustgi AK
Exact source Table 2S: Dec. in 2 x 3D exps
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Source species Homo sapiens
Contributed by Arthur Liberzon (MSigDB Team)
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identifier namespace		 AFFY_HG_U133
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Version history 3.1: First introduced

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