Human Gene Set: JINESH_BLEBBISHIELD_VS_LIVE_CONTROL_DN


Standard name JINESH_BLEBBISHIELD_VS_LIVE_CONTROL_DN
Systematic name M38973
Brief description Genes down-regulated in blebbishields compared to control RT4 live cells
Full description or abstract Apoptosis is a process that kills cells. However, cancer stem cells find ways to escape death after commencement of apoptosis. One such mechanism is blebbishield emergency program, in which the apoptotic cancer stem cells first undergo apoptotic body formation but then reassemble apoptotic bodies with main body (nuclei containing) of the apoptotic cells to form spherical to elongated structures called blebbishields. Blebbishields in turn are capable of blebbishield-blebbishield fusion to form transformed stem cell spheres (transformation phase) and then give rise to individual cancer cells from spheres (exit phase). We identified blebbishield emergency program in RT4 bladder cancer cells (RT4P=parental) and did microarray analysis of live RT4P cells, blebbishields and transformed spheres. This data set is a comparison of RT4P live cells with blebbishields and the gene list includes the genes that are downregulated in blebbishields. A separate set is provided for upregulated gene list too. In addition we provide separate gene lists for upregulated and downregulated gene lists for transformed spheres compared to blebbishields.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 28855211   Authors: Jinesh GG,Kamat AM
Exact source Figure-2B: Genes downregulated in blebbishields Log2Fold change <1.0
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Source species Homo sapiens
Contributed by Goodwin G. Jinesh and Ashish M. Kamat (UT MD Anderson Cancer Center)
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identifier namespace		 Human_ILLUMINA_Array
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