Human Gene Set: JIANG_MELANOMA_TRM2_CD8


Standard name JIANG_MELANOMA_TRM2_CD8
Systematic name M48966
Brief description  
Full description or abstract Tissue-resident memory T cells (TRM) are a specialized T cell population residing in peripheral tissues. The presence and potential impact of TRM in the tumor immune microenvironment (TIME) remain to be elucidated. Here, we systematically investigated the relationship between TRM and melanoma TIME based on multiple clinical single-cell RNA-seq datasets and developed signatures indicative of TRM infiltration. TRM infiltration is associated with longer overall survival and abundance of T cells, NK cells, M1 macrophages, and memory B cells in the TIME. A 22-gene TRM derived risk score was further developed to effectively classify patients into low- and high-risk categories, distinguishing overall survival and immune activation, particularly in T cell-mediated responses. Altogether, our analysis suggests that TRM abundance is associated with melanoma TIME activation and patient survival, and the TRM-based machine learning model can potentially predict prognosis in melanoma patients.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 38455971   Authors: Jiang C,Chao CC,Li J,Ge X,Shen A,Jucaud V,Cheng C,Shen X
Exact source Supplemental Table 1. Tissue resident memory T cells cluster-specific maker gene sets. Related to Figure 2.
Related gene sets (show 11 additional gene sets from the source publication)

(show 123 gene sets from the same authors)
External links https://www.cell.com/iscience/fulltext/S2589-0042(24)00498-X
Filtered by similarity ?
Source species Homo sapiens
Contributed by Anthony Castanza (MSigDB Team)
Source platform or
identifier namespace
HUMAN_GENE_SYMBOL
Dataset references  
Download gene set format: grp | gmt | xml | json | TSV metadata
Compute overlaps ? (show collections to investigate for overlap with this gene set)
Compendia expression profiles ? NG-CHM interactive heatmaps
(Please note that clustering takes a few seconds)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)

Legacy heatmaps (PNG)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query Further investigate these 146 genes
Gene families ? Categorize these 146 genes by gene family
Show members (show 147 source identifiers mapped to 146 genes)
Version history 2024.1.Hs: First Introduced.

See MSigDB license terms here. Please note that certain gene sets have special access terms.