Human Gene Set: IWANAGA_E2F1_TARGETS_INDUCED_BY_SERUM


Standard name IWANAGA_E2F1_TARGETS_INDUCED_BY_SERUM
Systematic name M1172
Brief description Genes up-regulated in REF52 cells (embryonic fibroblast) by expression of E2F1 [GeneID=1869] that were also induced at 16 hr after serum stimulation.
Full description or abstract The transcription factor E2F mediates cell cycle-dependent expression of genes important for cell proliferation in response to growth stimulation. To further understand the role of E2F, we utilized a sensitive subtraction method to explore new E2F1 targets, which are expressed at low levels and might have been unrecognized in previous studies. We identified 33 new E2F1-inducible genes, including checkpoint genes Claspin and Rad51ap1, and four genes with unknown function required for cell cycle progression. Moreover, we found three groups of E2F1-inducible genes that were not induced by growth stimulation. At least, two groups of genes were directly induced by E2F1, indicating that E2F1 can regulate expression of genes not induced during the cell cycle. One included Neogenin, WASF1 and SGEF genes, which may have a role in differentiation or development. The other was the cyclin-dependent kinase inhibitor p27(Kip1), which was involved in suppression of inappropriate cell cycle progression induced by deregulated E2F. E2F1-responsive regions of these genes were located more upstream than those of typical E2F targets and did not have typical E2F sites. These results indicate that there are groups of E2F1 targets, which are regulated in a distinct manner from that of typical E2F targets.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 16288221   Authors: Iwanaga R,Komori H,Ishida S,Okamura N,Nakayama K,Nakayama KI,Ohtani K
Exact source Table 2
Related gene sets (show 1 additional gene sets from the source publication)

(show 3 gene sets from the same authors)
External links
Filtered by similarity ?
Source species Rattus norvegicus
Contributed by Arthur Liberzon (MSigDB Team)
Source platform or
identifier namespace		 RAT_GENE_SYMBOL
Dataset references  
Download gene set format: grp | gmt | xml | json | TSV metadata
Compute overlaps ? (show collections to investigate for overlap with this gene set)
Compendia expression profiles ? NG-CHM interactive heatmaps
(Please note that clustering takes a few seconds)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)

Legacy heatmaps (PNG)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query Further investigate these 24 genes
Gene families ? Categorize these 24 genes by gene family
Show members (show 33 source identifiers mapped to 24 genes)
Version history 3.1: First introduced

See MSigDB license terms here. Please note that certain gene sets have special access terms.