Human Gene Set: IVANOVSKA_MIR106B_TARGETS


Standard name IVANOVSKA_MIR106B_TARGETS
Systematic name M2258
Brief description A consensus set of genes that were significantly down-regulated by MIR106B [GeneID=406900].
Full description or abstract microRNAs in the miR-106b family are overexpressed in multiple tumor types and are correlated with the expression of genes that regulate the cell cycle. Consistent with these observations, miR-106b family gain of function promotes cell cycle progression, whereas loss of function reverses this phenotype. Microarray profiling uncovers multiple targets of the family, including the cyclin-dependent kinase inhibitor p21/CDKN1A. We show that p21 is a direct target of miR-106b and that its silencing plays a key role in miR-106b-induced cell cycle phenotypes. We also show that miR-106b overrides a doxorubicin-induced DNA damage checkpoint. Thus, miR-106b family members contribute to tumor cell proliferation in part by regulating cell cycle progression and by modulating checkpoint functions.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 18212054   Authors: Ivanovska I,Ball AS,Diaz RL,Magnus JF,Kibukawa M,Schelter JM,Kobayashi SV,Lim L,Burchard J,Jackson AL,Linsley PS,Cleary MA
Exact source Table 1S
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Source species Homo sapiens
Contributed by Arthur Liberzon (MSigDB Team)
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identifier namespace		 HUMAN_SEQ_ACCESSION
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Version history 3.1: First introduced

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