Human Gene Set: IRITANI_MAD1_TARGETS_DN

For the Mouse gene set with the same name, see IRITANI_MAD1_TARGETS_DN

Standard name IRITANI_MAD1_TARGETS_DN
Systematic name M1944
Brief description Genes down-regulated by overexpression of MAD1 [GeneID=4084] in primary thymocytes from RAG2 [GeneID=5897] knockout mice.
Full description or abstract Activated lymphocytes must increase in size and duplicate their contents (cell growth) before they can divide. The molecular events that control cell growth in proliferating lymphocytes and other metazoan cells are still unclear. Here, we utilized transgenesis to provide evidence suggesting that the basic helix-loop- helix-zipper (bHLHZ) transcriptional repressor Mad1, considered to be an antagonist of Myc function, inhibits lymphocyte expansion, maturation and growth following pre-T-cell receptor (pre-TCR) and TCR stimulation. Furthermore, we utilized cDNA microarray technology to determine that, of the genes repressed by Mad1, the majority (77%) are involved in cell growth, which correlates with a decrease in size of Mad1 transgenic thymocytes. Over 80% of the genes repressed by Mad1 have previously been found to be induced by Myc. These results suggest that a balance between Myc and Mad levels may normally modulate lymphocyte proliferation and development in part by controlling expression of growth-regulating genes.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 12234922   Authors: Iritani BM,Delrow J,Grandori C,Gomez I,Klacking M,Carlos LS,Eisenman RN
Exact source Fig. 7B: Genes decreased by Mad1
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Source species Mus musculus
Contributed by Jessica Robertson (MSigDB Team)
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identifier namespace		 AFFY_Mu11K
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Version history 3.1: First introduced

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