Human Gene Set: IL2_UP.V1_DN


Standard name IL2_UP.V1_DN
Systematic name M2820
Brief description Genes down-regulated in Sez-4 cells (T lymphocyte) that were first starved of IL2 [GeneID=3558] and then stimulated with IL2 [GeneID=3558].
Full description or abstract Sez-4 cell line was starved of IL2 for 16h, washed twice and placed into 6-well plates in 10ml RPMI (10% FBS) for 2 h followed by addition of IL-2 (200U) or medium alone for 4 h.
Collection C6: Oncogenic Signature
Source publication Pubmed 18281483   Authors: Marzec M,Halasa K,Kasprzycka M,Wysocka M,Liu X,Tobias JW,Baldwin D,Zhang Q,Odum N,Rook AH,Wasik MA
Exact source Sez-4 cells starved of IL-2 and activated with IL-2 vs Sez-4 cells starved of IL-2; bottom 200 genes (diff. of means)
Related gene sets (show 19 additional gene sets from the source publication)

(show 165 gene sets from the same authors)
External links
Filtered by similarity ?
Source species Homo sapiens
Contributed by Pablo Tamayo (Broad Institute)
Source platform or
identifier namespace		 HUMAN_GENE_SYMBOL
Dataset references (show 1 datasets)
Download gene set format: grp | gmt | xml | json | TSV metadata
Compute overlaps ? (show collections to investigate for overlap with this gene set)
Compendia expression profiles ? NG-CHM interactive heatmaps
(Please note that clustering takes a few seconds)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)

Legacy heatmaps (PNG)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query Further investigate these 193 genes
Gene families ? Categorize these 193 genes by gene family
Show members (show 200 source identifiers mapped to 193 genes)
Version history  

See MSigDB license terms here. Please note that certain gene sets have special access terms.