| Standard name |
IBRAHIM_NRF3_UP |
| Systematic name |
M42511 |
| Brief description |
Transcripts up-regulated in HEK293T cells overexpressing FLAG-NRF3 |
| Full description or abstract |
The NRF transcription factors NRF1, NRF2, and NRF3, are a subset of Cap'n'collar transcriptional regulators which modulate the expression of genes harboring antioxidant-response element (ARE) sequences within their genomic loci. Despite the emerging physiological importance of NRF family members, the repertoire of their genetic targets remains incompletely defined. Here we use RNA-sequencing-based transcriptional profiling and quantitative proteomics to delineate the overlapping and differential genetic programs effected by the three NRF transcription factors. Comparing our data to recent profiling analyses, we create consensus target gene sets regulated by NRF1, NRF2, and NRF3, genetic programs which we determine to be differentially regulated in human tissues. Together, our data provide a quantitative assessment of how NRF family members sculpt proteomes and transcriptomes, essential information for future studies evaluating the role of NRF factors in normal physiology and disease. |
| Collection |
C2: Curated
CGP: Chemical and Genetic Perturbations |
| Source publication |
Pubmed 33096892 Authors: Ibrahim L,Mesgarzadeh J,Xu I,Powers ET,Wiseman RL,Bollong MJ |
| Exact source |
Table 6S: MSigDB Genesets |
| Related gene sets |
(show 5 additional gene sets from the source publication)
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| External links |
https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE159230
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| Filtered by similarity ?
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| Source species |
Homo sapiens |
| Contributed by |
Lara Ibrahim (The Scripps Research Institute) |
Source platform or
identifier namespace |
HUMAN_GENE_SYMBOL |
| Dataset references |
(show 1 datasets)
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GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Legacy heatmaps (PNG)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
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(show 7 source identifiers mapped to 7 genes)
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| Version history |
7.5: First Introduced.
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