Human Gene Set: IBRAHIM_NRF1_DOWN


Standard name IBRAHIM_NRF1_DOWN
Systematic name M42512
Brief description Genes down-regulated in HEK293T cells overexpressing FLAG-NRF1
Full description or abstract The NRF transcription factors NRF1, NRF2, and NRF3, are a subset of Cap'n'collar transcriptional regulators which modulate the expression of genes harboring antioxidant-response element (ARE) sequences within their genomic loci. Despite the emerging physiological importance of NRF family members, the repertoire of their genetic targets remains incompletely defined. Here we use RNA-sequencing-based transcriptional profiling and quantitative proteomics to delineate the overlapping and differential genetic programs effected by the three NRF transcription factors. Comparing our data to recent profiling analyses, we create consensus target gene sets regulated by NRF1, NRF2, and NRF3, genetic programs which we determine to be differentially regulated in human tissues. Together, our data provide a quantitative assessment of how NRF family members sculpt proteomes and transcriptomes, essential information for future studies evaluating the role of NRF factors in normal physiology and disease.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 33096892   Authors: Ibrahim L,Mesgarzadeh J,Xu I,Powers ET,Wiseman RL,Bollong MJ
Exact source Table 6S: MSigDB Genesets
Related gene sets (show 5 additional gene sets from the source publication)
External links https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE159230
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Source species Homo sapiens
Contributed by Lara Ibrahim (The Scripps Research Institute)
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identifier namespace		 HUMAN_GENE_SYMBOL
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Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
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