Human Gene Set: HUANG_AML_LSC47


Standard name HUANG_AML_LSC47
Systematic name M48362
Brief description Genes up-regulated in AML leukemia stem cells (LSC) and predictive for outcome in AML
Full description or abstract Relapsed or refractory pediatric acute myeloid leukemia (AML) is associated with poor outcomes and relapse risk prediction approaches have not changed significantly in decades. To build a robust transcriptional risk prediction model for pediatric AML, we perform RNA-sequencing on 1503 primary diagnostic samples. While a 17 gene leukemia stem cell signature (LSC17) is predictive in our aggregated pediatric study population, LSC17 is no longer predictive within established cytogenetic and molecular (cytomolecular) risk groups. Therefore, we identify distinct LSC signatures on the basis of AML cytomolecular subtypes (LSC47) that were more predictive than LSC17. Based on these findings, we build a robust relapse prediction model within a training cohort and then validate it within independent cohorts. Here, we show that LSC47 increases the predictive power of conventional risk stratification and that applying biomarkers in a manner that is informed by cytomolecular profiling outperforms a uniform biomarker approach.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 36123353   Authors: Huang BJ,Smith JL,Farrar JE,Wang YC,Umeda M,Ries RE,Leonti AR,Crowgey E,Furlan SN,Tarlock K,Armendariz M,Liu Y,Shaw TI,Wei L,Gerbing RB,Cooper TM,Gamis AS,Aplenc R,Kolb EA,Rubnitz J,Ma J,Klco JM,Ma X,Alonzo TA,Triche T Jr,Meshinchi S
Exact source Table 1S: LSC47
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Source species Homo sapiens
Contributed by Benjamin Huang (University of California San Francisco)
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identifier namespace		 Human_NCBI_Gene_ID
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Version history 2024.1.Hs: First Introduced.

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