Human Gene Set: HP_IMPAIRED_ANTIGEN_SPECIFIC_RESPONSE


Standard name HP_IMPAIRED_ANTIGEN_SPECIFIC_RESPONSE
Systematic name M38470
Brief description Impaired antigen-specific response
Full description or abstract An impaired immune response mediated by cells expressing specific receptors for antigen produced through a somatic diversification process, and allowing for an enhanced secondary response to subsequent exposures to the same antigen (immunological memory). []
Collection C5: Ontology
      HPO: Human Phenotype Ontology
Source publication  
Exact source HP:0031404
Related gene sets  
External links https://hpo.jax.org/app/browse/term/HP:0031404
Filtered by similarity ?
Source species Homo sapiens
Contributed by Human Phenotype Ontology Group (The Jackson Laboratory (JAX))
Source platform or
identifier namespace
Human_NCBI_Gene_ID
Dataset references  
Download gene set format: grp | gmt | xml | json | TSV metadata
Compute overlaps ? (show collections to investigate for overlap with this gene set)
Compendia expression profiles ? NG-CHM interactive heatmaps
(Please note that clustering takes a few seconds)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)

Legacy heatmaps (PNG)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query Further investigate these 63 genes
Gene families ? Categorize these 63 genes by gene family
Show members (show 63 source identifiers mapped to 63 genes)
Version history 2026.1.Hs: Updated to HPO Release 2026-01-08.


Creative Commons Attribution 4.0 International License (CC-BY-4.0)

The contents of this gene set are protected by copyright (c) 2004-2026 Broad Institute, Inc., Massachusetts Institute of Technology, and Regents of the University of California, subject to the terms and conditions of the Creative Commons Attribution 4.0 International License.

See the full MSigDB license terms here.