Human Gene Set: HP_ABNORMAL_RESPONSE_TO_INSULIN_TOLERANCE_TEST
Standard name
HP_ABNORMAL_RESPONSE_TO_INSULIN_TOLERANCE_TEST
Systematic name
M43496
Brief description
Abnormal response to insulin tolerance test
Full description or abstract
An anomalous response to the insulin tolerance test (ITT), in which insulin is administered intravenously and blood glucose and potentially other compounds are measured at intervals. Insulin administration is intended to induce extreme hypoglycemia (bloodgluoce below 40 mg/dl), which in turn induces release of adrenocorticotropic hormone (ACTH) and growth hormone (GH). ACTH induces the adrenal gland to release cortisol, which together with GH opposes the action of insulin on the blood glucose level. []
