Human Gene Set: HP_ABNORMAL_CIRCULATING_GLOBULIN_CONCENTRATION
Standard name
HP_ABNORMAL_CIRCULATING_GLOBULIN_CONCENTRATION
Systematic name
M38530
Brief description
Abnormal circulating globulin concentration
Full description or abstract
An abnormal concentration of globulins in the blood. Albumin makes up more than half of the total protein present in serum. The remaining blood proteins except albumin and fibrinogen (which is not in serum) are referred to as globulins. The globulin fraction includes hundreds of serum proteins including carrier proteins, enzymes, complement, and immunoglobulins. Most of these are synthesized in the liver, although the immunoglobulins are synthesized by plasma cells. Globulins are divided into four groups by electrophoresis. The four fractions are alpha1, alpha2, beta and gamma, depending on their migratory pattern between the anode and the cathode. []
