Human Gene Set: HOOI_ST7_TARGETS_DN


Standard name HOOI_ST7_TARGETS_DN
Systematic name M14801
Brief description Genes down-regulated in PC-3 cells (prostate cancer) stably expressing ST7 [GeneID=7982] off a plasmid vector.
Full description or abstract Multiple lines of evidence have provided compelling evidence for the existence of a tumor suppressor gene (TSG) on chromosome 7q31.1. ST7 may be the target of this genetic instability but its designation as a TSG is controversial. In this study, we show that, functionally, ST7 behaves as a tumor suppressor in human cancer. ST7 suppressed growth of PC-3 prostate cancer cells inoculated subcutaneously into severe combined immunodeficient mice, and increased the latency of tumor detection from 13 days in control tumors to 23 days. Re-expression of ST7 was also associated with suppression of colony formation under anchorage-independent conditions in MDA-MB-231 breast cancer cells and ST7 mRNA expression was downregulated in 44% of primary breast cancers. Expression profiling of PC-3 cells revealed that ST7 predominantly induces changes in genes involved in re-modeling the extracellular matrix such as SPARC, IGFBP5 and several matrix metalloproteinases. These data indicate that ST7 may mediate tumor suppression through modification of the tumor microenvironment.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 16474848   Authors: Hooi CF,Blancher C,Qiu W,Revet IM,Williams LH,Ciavarella ML,Anderson RL,Thompson EW,Connor A,Phillips WA,Campbell IG
Exact source Table S1 Fold change < 0.5
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Source species Homo sapiens
Contributed by Leona Saunders (MSigDB Team)
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identifier namespace		 AFFY_HG_U133
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Version history 3.0: First introduced


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