Human Gene Set: HOLLEMAN_DAUNORUBICIN_B_ALL_DN


Standard name HOLLEMAN_DAUNORUBICIN_B_ALL_DN
Systematic name M2557
Brief description Genes distinguishing daunorubicin [PubChem=30323] resistant and sensitive B-lineage ALL; here - genes down-regulated in the drug resistant samples.
Full description or abstract Childhood acute lymphoblastic leukemia (ALL) is curable with chemotherapy in approximately 80 percent of patients. However, the cause of treatment failure in the remaining 20 percent of patients is largely unknown.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 15295046   Authors: Holleman A,Cheok MH,den Boer ML,Yang W,Veerman AJ,Kazemier KM,Pei D,Cheng C,Pui CH,Relling MV,Janka-Schaub GE,Pieters R,Evans WE
Exact source Fig. 8S: R/S ratio < 1
Related gene sets (show 15 additional gene sets from the source publication)

(show 40 gene sets from any of these authors)
External links
Filtered by similarity ?
Source species Homo sapiens
Contributed by Arthur Liberzon (MSigDB Team)
Source platform or
identifier namespace		 AFFY_HG_U133
Dataset references (show 1 datasets)
Download gene set format: grp | gmt | xml | json | TSV metadata
Compute overlaps ? (show collections to investigate for overlap with this gene set)
Compendia expression profiles ? NG-CHM interactive heatmaps
(Please note that clustering takes a few seconds)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)

Legacy heatmaps (PNG)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query Further investigate these 12 genes
Gene families ? Categorize these 12 genes by gene family
Show members (show 12 source identifiers mapped to 12 genes)
Version history 3.1: First introduced


Creative Commons Attribution 4.0 International License (CC-BY-4.0)

The contents of this gene set are protected by copyright (c) 2004-2026 Broad Institute, Inc., Massachusetts Institute of Technology, and Regents of the University of California, subject to the terms and conditions of the Creative Commons Attribution 4.0 International License.

See the full MSigDB license terms here.