Human Gene Set: HOEGERKORP_CD44_TARGETS_TEMPORAL_DN


Standard name HOEGERKORP_CD44_TARGETS_TEMPORAL_DN
Systematic name M11025
Brief description Genes temporally down-regulated by CD44 [GeneID=960] stimulation of B lymphocytes.
Full description or abstract A number of studies have implicated a role for the cell surface glycoprotein CD44 in several biologic events, such as lymphopoiesis, homing, lymphocyte activation, and apoptosis. We have earlier reported that signaling via CD44 on naive B cells in addition to B-cell receptor (BCR) and CD40 engagement generated a germinal center-like phenotype. To further characterize the global role of CD44 in B differentiation, we examined the expression profile of human B cells cultured in vitro in the presence or absence of CD44 ligation, together with anti-immunoglobulin (anti-Ig) and anti-CD40 antibodies. The data sets derived from DNA microarrays were analyzed using a novel statistical analysis scheme created to retrieve the most likely expression pattern of CD44 ligation. Our results show that genes such as interleukin-6 (IL-6), IL-1alpha, and beta(2)-adrenergic receptor (beta(2)-AR) were specifically up-regulated by CD44 ligation, suggesting a novel role for CD44 in immunoregulation and inflammation.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 12411303   Authors: Högerkorp CM,Bilke S,Breslin T,Ingvarsson S,Borrebaeck CA
Exact source Table 4
Related gene sets (show 3 additional gene sets from the source publication)

(show 5 gene sets from the same authors)
External links
Filtered by similarity ?
Source species Homo sapiens
Contributed by Kevin Vogelsang (MSigDB Team)
Source platform or
identifier namespace		 AFFY_HuGene
Dataset references  
Download gene set format: grp | gmt | xml | json | TSV metadata
Compute overlaps ? (show collections to investigate for overlap with this gene set)
Compendia expression profiles ? NG-CHM interactive heatmaps
(Please note that clustering takes a few seconds)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)

Legacy heatmaps (PNG)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query Further investigate these 25 genes
Gene families ? Categorize these 25 genes by gene family
Show members (show 25 source identifiers mapped to 25 genes)
Version history 3.0: Renamed from HOGERKORP_CD44_TEMPORALLY_UP

See MSigDB license terms here. Please note that certain gene sets have special access terms.