Human Gene Set: HIRSCH_CELLULAR_TRANSFORMATION_SIGNATURE_DN


Standard name HIRSCH_CELLULAR_TRANSFORMATION_SIGNATURE_DN
Systematic name M2124
Brief description Down-regulated genes in the cancer gene signature, representing a gene signature of cellular transformation.
Full description or abstract Transcriptional profiling of two isogenic models of transformation identifies a gene signature linking cancer with inflammatory and metabolic diseases. In accord with this common transcriptional program, many drugs used for treatment of diabetes and cardiovascular diseases inhibit transformation and tumor growth. Unexpectedly, lipid metabolism genes are important for transformation and are upregulated in cancer tissues. As in atherosclerosis, oxidized LDL and its receptor OLR1 activate the inflammatory pathway through NF-kappaB, leading to transformation. OLR1 is important for maintaining the transformed state in developmentally diverse cancer cell lines and for tumor growth, suggesting a molecular connection between cancer and atherosclerosis. We suggest that the interplay between this common transcriptional program and cell-type-specific factors gives rise to phenotypically disparate human diseases.
Collection C2: Curated
      CGP: Chemical and Genetic Perturbations
Source publication Pubmed 20385360   Authors: Hirsch HA,Iliopoulos D,Joshi A,Zhang Y,Jaeger SA,Bulyk M,Tsichlis PN,Shirley Liu X,Struhl K
Exact source Table 3S: Downregulated
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Source species Homo sapiens
Contributed by Arthur Liberzon (MSigDB Team)
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identifier namespace		 HUMAN_GENE_SYMBOL
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Version history 3.1: First introduced

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