Human Gene Set: GSE9650_NAIVE_VS_EXHAUSTED_CD8_TCELL_DN


Standard name GSE9650_NAIVE_VS_EXHAUSTED_CD8_TCELL_DN
Systematic name M5828
Brief description Genes down-regulated in comparison of naive CD8 T cells versus exhausted CD8 T cells.
Full description or abstract CD8 T cells normally differentiate from resting naïve T cells into function effector and then memory CD8 T cells following acute infections. During chronic viral infections, however, virus-specific CD8 T cells often become exhausted. We used microarrays to examine the gene expression differences between naive, effector, memory and exhausted virus-specific CD8 T cells following lymphocytic choriomeningitis virus infection.
Collection C7: Immunologic Signature
      IMMUNESIGDB: ImmuneSigDB
Source publication Pubmed 17950003   Authors: Wherry EJ,Ha SJ,Kaech SM,Haining WN,Sarkar S,Kalia V,Subramaniam S,Blattman JN,Barber DL,Ahmed R
Exact source GSE9650_1254_200_DN
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Source species Mus musculus
Contributed by Jernej Godec (Dana-Farber Cancer Institute)
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identifier namespace		 HUMAN_GENE_SYMBOL
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Version history 7.3: Moved to ImmuneSigDB sub-collection.

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