Human Gene Set: GSE8921_3H_VS_24H_TLR1_2_STIM_MONOCYTE_DN


Standard name GSE8921_3H_VS_24H_TLR1_2_STIM_MONOCYTE_DN
Systematic name M6425
Brief description Genes down-regulated in monocytes in response to M. tuberculosis 19 kDa lipopeptide: 3h versus 24h.
Full description or abstract In innate immune responses, activation of Toll-like receptors (TLRs) triggers direct antimicrobial activity against intracellular bacteria, which in murine, but not human, monocytes and macrophages is mediated principally by nitric oxide. We report here that TLR activation of human macrophages up-regulated expression of the vitamin D receptor and the vitamin D-1-hydroxylase genes, leading to induction of the antimicrobial peptide cathelicidin and killing of intracellular Mycobacterium tuberculosis. We also observed that sera from African-American individuals, known to have increased susceptibility to tuberculosis, had low 25-hydroxyvitamin D and were inefficient in supporting cathelicidin messenger RNA induction. These data support a link between TLRs and vitamin D-mediated innate immunity and suggest that differences in ability of human populations to produce vitamin D may contribute to susceptibility to microbial infection.
Collection C7: Immunologic Signature
      IMMUNESIGDB: ImmuneSigDB
Source publication Pubmed 16497887   Authors: Liu PT,Stenger S,Li H,Wenzel L,Tan BH,Krutzik SR,Ochoa MT,Schauber J,Wu K,Meinken C,Kamen DL,Wagner M,Bals R,Steinmeyer A,Zügel U,Gallo RL,Eisenberg D,Hewison M,Hollis BW,Adams JS,Bloom BR,Modlin RL
Exact source GSE8921_3129_200_DN
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Source species Homo sapiens
Contributed by Jernej Godec (Dana-Farber Cancer Institute)
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identifier namespace		 HUMAN_GENE_SYMBOL
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Version history 7.3: Moved to ImmuneSigDB sub-collection.

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