Human Gene Set: GSE7509_UNSTIM_VS_FCGRIIB_STIM_DC_DN


Standard name GSE7509_UNSTIM_VS_FCGRIIB_STIM_DC_DN
Systematic name M6818
Brief description Genes down-regulated in dendritic cells: untreated versus anti-FcgRIIB.
Full description or abstract The ability of dendritic cells (DCs) to activate immunity is linked to their maturation status. In prior studies we have shown that selective antibody-mediated blockade of inhibitory FcgRIIB receptor on human DCs in the presence of activating immunoglobulin (Ig) ligands leads to DC maturation and enhanced immunity to antibody-coated tumor cells. Here we show that Fcg receptor (FcgR) mediated activation of human monocytes and monocyte-derived DCs is associated with a distinct gene expression pattern, including several inflammation associated chemokines as well as type 1 interferon (IFN) response genes including the activation of signal transducer and activator of transcription 1 (STAT1).
Collection C7: Immunologic Signature
      IMMUNESIGDB: ImmuneSigDB
Source publication Pubmed 17502666   Authors: Dhodapkar KM,Banerjee D,Connolly J,Kukreja A,Matayeva E,Veri MC,Ravetch JV,Steinman RM,Dhodapkar MV
Exact source GSE7509_3403_200_DN
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Source species Homo sapiens
Contributed by Jernej Godec (Dana-Farber Cancer Institute)
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Version history 7.3: Moved to ImmuneSigDB sub-collection.

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