Human Gene Set: GSE7460_WT_VS_FOXP3_HET_ACT_WITH_TGFB_TCONV_DN


Standard name GSE7460_WT_VS_FOXP3_HET_ACT_WITH_TGFB_TCONV_DN
Systematic name M5712
Brief description Genes down-regulated in comparison of ActCD4TGF versus WTActCD4TGF (see Fig. 1 in the paper for details).
Full description or abstract The transcription factor Foxp3 is usually considered the master regulator for the CD4+CD25+ "Treg" lineage, which plays a key role in controlling immune and autoimmune responses, and is characterized by a unique transcriptional signature. We have performed a meta-analysis of this signature in Treg cells in several conditions to delineate the elements that can be ascribed to T cell activation, TGFbeta signaling, or Foxp3 itself. We find that these influences synergize to activate many of the signature?s components. Foxp3 and TGFbeta signaling have interconnected relationships, as Foxp3 is induced by TGFbeta while enhancing TGFbeta?s positive feedback loop. Much of the Treg signature cannot be ascribed to Foxp3, as it contains gene clusters that are co-regulated, but cannot be transactivated, by Foxp3. This suggests that the Treg lineage is specified at a higher level of regulation, upstream of Foxp3, which does control some of the lineage?s essential immunoregulatory attributes.
Collection C7: Immunologic Signature
      IMMUNESIGDB: ImmuneSigDB
Source publication Pubmed 18024188   Authors: Hill JA,Feuerer M,Tash K,Haxhinasto S,Perez J,Melamed R,Mathis D,Benoist C
Exact source GSE7460_1343_200_DN
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Source species Homo sapiens
Contributed by Jernej Godec (Dana-Farber Cancer Institute)
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identifier namespace		 HUMAN_GENE_SYMBOL
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Version history 7.3: Moved to ImmuneSigDB sub-collection.

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