Human Gene Set: GSE45365_WT_VS_IFNAR_KO_BCELL_MCMV_INFECTION_DN
Standard name
GSE45365_WT_VS_IFNAR_KO_BCELL_MCMV_INFECTION_DN
Systematic name
M9989
Brief description
Genes down-regulated in CD8 T cells: control versus primary acute viral infection.
Full description or abstract
Murine Cytomegalovirus (MCMV) infection leads to early activation of various immune cells, including B and T lymphocytes, before the actual initiation of antigen-specific adaptive immunity. This activation is partly driven by innate cytokines, including type I interferon (IFN), which are induced early after infection. The objective of this study was to address the role of type I IFN in shaping early/innate B and T cell responses to a primary acute viral infection. In order to decipher the specific impact of IFN-I on cell subsets, we performed a genome-wide expression analysis on WT splenic B and CD8 T lymphocytes isolated from C57BL/6 [CD45.1 WT / CD45.2 IFNAR-KO] mixed bone marrow chimera mice. This study complements series GSE39555, which focused on early responses of NK cells and of the two subsets of conventional dendritic cells.
