Human Gene Set: GSE41176_UNSTIM_VS_ANTI_IGM_STIM_BCELL_24H_DN


Standard name GSE41176_UNSTIM_VS_ANTI_IGM_STIM_BCELL_24H_DN
Systematic name M9925
Brief description Genes down-regulated in B lymphocytes: untreated versus anti-IgM for 24h.
Full description or abstract The activation signaling of transcription factor nuclear factor-kB (NF-kB) plays central role for immune system. One of key kinase mediating this pathway is TAK1 in adaptive and innate immunity. However, role of TAK1 in B cell receptor signaling is still unclear. To know effects of TAK1-deletion on the gene expression induced by anti-IgM, we performed the time course analysis in comparison of wild type with TAK1-deleted splenic B cells.
Collection C7: Immunologic Signature
      IMMUNESIGDB: ImmuneSigDB
Source publication Pubmed 24833394   Authors: Shinohara H,Behar M,Inoue K,Hiroshima M,Yasuda T,Nagashima T,Kimura S,Sanjo H,Maeda S,Yumoto N,Ki S,Akira S,Sako Y,Hoffmann A,Kurosaki T,Okada-Hatakeyama M
Exact source GSE41176_3678_200_DN
Related gene sets (show 25 additional gene sets from the source publication)

(show 83 gene sets from the same authors)
External links
Filtered by similarity ?
Source species Mus musculus
Contributed by Jernej Godec (Dana-Farber Cancer Institute)
Source platform or
identifier namespace		 HUMAN_GENE_SYMBOL
Dataset references (show 1 datasets)
Download gene set format: grp | gmt | xml | json | TSV metadata
Compute overlaps ? (show collections to investigate for overlap with this gene set)
Compendia expression profiles ? NG-CHM interactive heatmaps
(Please note that clustering takes a few seconds)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)

Legacy heatmaps (PNG)
GTEx compendium
Human tissue compendium (Novartis)
Global Cancer Map (Broad Institute)
NCI-60 cell lines (National Cancer Institute)
Advanced query Further investigate these 200 genes
Gene families ? Categorize these 200 genes by gene family
Show members (show 200 source identifiers mapped to 200 genes)
Version history 7.3: Moved to ImmuneSigDB sub-collection.

See MSigDB license terms here. Please note that certain gene sets have special access terms.