Human Gene Set: GSE3994_WT_VS_PAC1_KO_ACTIVATED_MAST_CELL_DN


Standard name GSE3994_WT_VS_PAC1_KO_ACTIVATED_MAST_CELL_DN
Systematic name M6372
Brief description Genes down-regulated in bone marrow-derived mast cells: wildtype versus ADCYAP1R1 [GeneID=117] knockout.
Full description or abstract Bone marrow-derived mast cells were differentiated over 4-6 weeks using bone marrow from Pac-1+/+ and Pac1-/- littermate mice. Cell purity was 99% c-kit and Fc epsilon receptor positive as assessed by flow cytometry. Cells were stimulated by Fc epsilon receptor crosslinking using IgE-DNP/HSA for sensitization for 18 hours and DNP-HSA antigen for crosslinking for 2 hours. Gene transcript abundance was determined and scaled to 150 using alogorithms in MicroArray Analysis Suite Software 5.0 (Affymetrix).
Collection C7: Immunologic Signature
      IMMUNESIGDB: ImmuneSigDB
Source publication Pubmed 16474395   Authors: Jeffrey KL,Brummer T,Rolph MS,Liu SM,Callejas NA,Grumont RJ,Gillieron C,Mackay F,Grey S,Camps M,Rommel C,Gerondakis SD,Mackay CR
Exact source GSE3994_2711_200_DN
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Source species Mus musculus
Contributed by Jernej Godec (Dana-Farber Cancer Institute)
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identifier namespace		 HUMAN_GENE_SYMBOL
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Version history 7.3: Moved to ImmuneSigDB sub-collection.

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