Human Gene Set: GSE3982_DC_VS_MAC_LPS_STIM_DN


Standard name GSE3982_DC_VS_MAC_LPS_STIM_DN
Systematic name M5390
Brief description Genes down-regulated in comparison of dendritic cells (DC) stimulatd with LPS (TLR4 agonist) at 48 h versus macrophages stimulated with LPS (TLR4 agonist) at 4 h.
Full description or abstract In the present study we used Affymetrix oligonucleotide microarrays to produce gene transcription profiles for the major leukocyte types in humans. This comprehensive dataset enabled us to not only establish which genes were expressed in each leukocyte type, but also which genes were expressed in each subset after activation. The used of a comprehensive dataset of gene profiles from all the major human leukocyte subsets enabled a novel and powerful means for identification of genes associated with single leukocyte subsets, or different immune paradigms.
Collection C7: Immunologic Signature
      IMMUNESIGDB: ImmuneSigDB
Source publication Pubmed 16474395   Authors: Jeffrey KL,Brummer T,Rolph MS,Liu SM,Callejas NA,Grumont RJ,Gillieron C,Mackay F,Grey S,Camps M,Rommel C,Gerondakis SD,Mackay CR
Exact source GSE3982_1769_200_DN
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Source species Homo sapiens
Contributed by Jernej Godec (Dana-Farber Cancer Institute)
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identifier namespace		 HUMAN_GENE_SYMBOL
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Version history 7.3: Moved to ImmuneSigDB sub-collection.

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