Human Gene Set: GSE38304_MYC_NEG_VS_POS_GC_BCELL_DN


Standard name GSE38304_MYC_NEG_VS_POS_GC_BCELL_DN
Systematic name M9274
Brief description Genes down-regulated in germinal celter B lymphocytes: MYC- [GeneID=4609] versus MYC+ [GeneID=4609].
Full description or abstract Germinal centers (GC) arise within B cell follicles upon antigenic challenge. In the dark zones (DZ) of GCs, B cells proliferate and hypermutate their immunoglobulin genes, and mutants with increased affinity are positively selected in the light zone (LZ) to either differentiate into plasma and memory cells, or re-enter the DZ for further refinement. However, the molecular circuits governing GC positive selection are not known. Here, we show that the GC reaction requires the biphasic regulation of c-MYC expression, involving its transient induction during early GC commitment, its repression by BCL6 in DZ B cells, and its re-induction in a subpopulation of positively selected LZ B cells destined to DZ re-entry. Accordingly, acute disruption of MYC function in vivo leads to GC collapse, indicating an essential role in GC physiology. These results have implications for our understanding of GC selection and the role of MYC deregulation in B cell lymphomas. We used microarrays to determine the global gene expression programs that distinguish MYC+ GC B cells from their MYC- negative counterparts.
Collection C7: Immunologic Signature
      IMMUNESIGDB: ImmuneSigDB
Source publication Pubmed 23001145   Authors: Dominguez-Sola D,Victora GD,Ying CY,Phan RT,Saito M,Nussenzweig MC,Dalla-Favera R
Exact source GSE38304_2936_200_DN
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Source species Mus musculus
Contributed by Jernej Godec (Dana-Farber Cancer Institute)
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Version history 7.3: Moved to ImmuneSigDB sub-collection.

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